MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms

被引：77

作者：

Gifford, Valentina ^{[1
]}

Itoh, Yoshifumi ^{[1
]}

机构：

[1] Univ Oxford, Kennedy Inst Rheumatol, Oxford, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2019年 / 47卷

基金：

英国医学研究理事会;

关键词：

TYPE-1; MATRIX-METALLOPROTEINASE; GELATINASE-A ACTIVATION; EXTRACELLULAR-MATRIX; TISSUE INHIBITOR; CYTOPLASMIC TAIL; TUMOR INVASION; 3-DIMENSIONAL INVASION; PROMMP-2; ACTIVATION; MEDIATED REGULATION; MT1-MMP EXPRESSION;

D O I：

10.1042/BST20180363

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier of cellular microenvironment and promotes cell migration and invasion of a wide variety of cell types both in physiological and pathological conditions. It promotes cell migration by degrading extracellular matrix on the cell surface and creates a migration path, by modifying cell adhesion property by shedding cell adhesion molecules to increase cell motility, and by altering cellular metabolism. Thus, MT1-MMP is a multifunctional cell motility enhancer. In this review, we will discuss the current understanding of the proteolytic and non-proteolytic mechanism of MT1-MMP-dependent cell migration.

引用

页码：811 / 826

页数：16

共 138 条

[1] LOCOMOTION OF FIBROBLASTS IN CULTURE .2. RUFFLING [J].

ABERCROMBIE, M ;

HEAYSMAN, JE ;

PEGRUM, SM .

EXPERIMENTAL CELL RESEARCH, 1970, 60 (03) :437-+

[2] LOCOMOTION OF FIBROBLASTS IN CULTURE .3. MOVEMENTS OF PARTICLES ON DORSAL SURFACE OF LEADING LAMELLA [J].

ABERCROMBIE, M ;

HEAYSMAN, JE ;

PEGRUM, SM .

EXPERIMENTAL CELL RESEARCH, 1970, 62 (2-3) :389-+

[3] LOCOMOTION OF FIBROBLASTS IN CULTURE .1. MOVEMENTS OF LEADING EDGE [J].

ABERCROMBIE, M ;

HEAYSMAN, JE ;

PEGRUM, SM .

EXPERIMENTAL CELL RESEARCH, 1970, 59 (03) :393-+

[4] Matrix metalloproteinase collagenolysis in health and disease [J].

Amar, Sabrina ;

Smith, Lyndsay ;

Fields, Gregg B. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2017, 1864 (11) :1940-1951

[5] Palmitoylation at Cys574 is essential for MT1-MMP to promote cell migration [J].

Anilkumar, N ;

Uekita, T ;

Couchman, JR ;

Nagase, H ;

Seiki, M ;

Itoh, Y .

FASEB JOURNAL, 2005, 19 (08) :1326-+

[6] Membrane type-1 matrix metalloproteinase (MT1-MMP) processing of pro-αv integrin regulates cross-talk between αvβ3 and α2β1 integrins in breast carcinoma cells [J].

Baciu, PC ;

Suleiman, EA ;

Deryugina, EI ;

Strongin, AY .

EXPERIMENTAL CELL RESEARCH, 2003, 291 (01) :167-175

[7] RNA interference screening identifies clathrin-B and cofilin-1 as mediators of MT1-MMP in endometrial cancer [J].

Baker, Tabari M. ;

Waheed, Sana ;

Syed, Viqar .

EXPERIMENTAL CELL RESEARCH, 2018, 370 (02) :663-670

[8] Endophilin A2 Promotes TNBC Cell Invasion and Tumor Metastasis [J].

Baldassarre, Tomas ;

Watt, Kathleen ;

Truesdell, Peter ;

Meens, Jalna ;

Schneider, Mark M. ;

Sengupta, Sandip K. ;

Craig, Andrew W. .

MOLECULAR CANCER RESEARCH, 2015, 13 (06) :1044-1055

[9] MT1-MMP proinvasive activity is regulated by a novel Rab8-dependent exocytic pathway [J].

Bravo-Cordero, Jose J. ;

Marrero-Diaz, Raquel ;

Megias, Diego ;

Genis, Laura ;

Garcia-Grande, Aranzazu ;

Garcia, Maria A. ;

Arroyo, Alicia G. ;

Montoya, Maria C. .

EMBO JOURNAL, 2007, 26 (06) :1499-1510

[10] Coronin 1C promotes triple-negative breast cancer invasiveness through regulation of MT1-MMP traffic and invadopodia function [J].

Castagnino, Alessia ;

Castro-Castro, Antonio ;

Irondelle, Marie ;

Guichard, Alan ;

Lodillinsky, Catalina ;

Fuhrmann, Laetitia ;

Vacher, Sophie ;

Aguera-Gonzalez, Sonia ;

Zagryazhskaya-Masson, Anna ;

Romao, Maryse ;

El Kesrouani, Carole ;

Noegel, Angelika A. ;

Dubois, Thierry ;

Raposo, Graca ;

Bear, James E. ;

Clemen, Christoph S. ;

Vincent-Salomon, Anne ;

Bieche, Ivan ;

Chavrier, Philippe .

ONCOGENE, 2018, 37 (50) :6425-6441

← 1 2 3 4 5 6 7 8 9 10 →