Effect of Physiochemical Properties on the Release Profile of Diltiazem HCl and Naproxen from HPMC and Kollidon SR based Matrix Tablets

被引:0
|
作者
Islam, Mohammad Safiqul
Moghal, Md. Mizanur Rahman
Doula, A. F. M. Shahid Ud
机构
关键词
Matrix tablet; Diltiazem hydrochloride; Naproxen; Kollidon SR; HPMC; THERAPEUTIC USE; FORMULATION; REAPPRAISAL; POLYMERS;
D O I
暂无
中图分类号
G40 [教育学];
学科分类号
040101 ; 120403 ;
摘要
The present study was undertaken to investigate the effect of Physiochemical properties on the release profile of drug from matrix systems. As the physico-chemical nature of the active ingredients influence the drug retarding ability of these polymers, two different drugs were used to evaluate their comparative release characteristics in similar matrices. Matrix tablets of Naproxen (NPR) and Diltiazem HCl (DTZ) using Hydroxypropyl Methylcellulose (HPMC-15cps) were prepared separately by direct compression process. The USP Basket method was selected to perform the dissolution test carried out in 1000 ml phosphate buffer of pH 6.8 for 8 hours. Statistically significant differences were found among the drug release profile from different classes of polymeric matrices. The release kinetics was found to be governed by the type and content of polymer in the matrix system. Higher polymeric content in the matrix decreased the release rate of drug because of increased tortuosity and decreased porosity. At lower polymeric level, the rate and extent of drug release were elevated. Release rate was also found to be the function of physico-chemical nature of drug molecule. Diltiazem HCl, being soluble in nature, released faster than Naproxen from all matrix systems. The release mechanism was explored and explained with biexponential equation. Release profile showed a tendency to follow Korsmeyer kinetics from matrix systems. The mean dissolution time (MDT) was calculated for all the formulations and the highest MDT value was obtained with Naproxen. The results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer level and physico-chemical nature of drug.
引用
收藏
页码:46 / 54
页数:9
相关论文
共 40 条
  • [1] In vitro release kinetics study of diltiazem hydrochloride from wax and Kollidon SR based matrix tablets
    Islam, Mohammad Safiqul
    Reza, Selim
    Rahman, Habibur
    IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2008, 7 (02): : 101 - 108
  • [2] Effect of Kollidon® SR on the release of Albuterol Sulphate from matrix tablets
    Sakr, Walid
    Alanazi, Fars
    Sakr, Adel
    SAUDI PHARMACEUTICAL JOURNAL, 2011, 19 (01) : 19 - 27
  • [3] EFFECT OF CHANNELING AGENTS ON THE RELEASE PATTERN OF THEOPHYLLINE FROM KOLLIDON SR BASED MATRIX TABLETS
    Ibn Razzak, Md. Shaikhul Millat
    Khan, Ferdous
    Hossain, Masuma
    Khan, Md. Ziaur Rahman
    Azad, Mohammad Abul Kalam
    Reza, Md. Selim
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 22 (03) : 303 - 307
  • [4] Effect of solvent on retarding the release of diltiazem HCl from Polyox-based liquisolid tablets
    Kaialy, Waseem
    Bello, Hussaini
    Asare-Addo, Kofi
    Nokhodchi, Ali
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2016, 68 (11) : 1396 - 1402
  • [5] The effect of chemical heterogeneity of HPMC on polymer release from matrix tablets
    Viriden, Anna
    Wittgren, Bengt
    Andersson, Thomas
    Larsson, Anette
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2009, 36 (4-5) : 392 - 400
  • [6] The effect of substitution pattern of HPMC on polymer release from matrix tablets
    Viriden, Anna
    Larsson, Anette
    Wittgren, Bengt
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2010, 389 (1-2) : 147 - 156
  • [7] EFFECT OF FORMULATION VARIABLES ON THE RELEASE OF ACECLOFENAC FROM HPMC MATRIX TABLETS
    Mettu, S. R.
    Veerareddy, P. R.
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2011, 2 (11): : 2901 - 2907
  • [8] EFFECT OF HPMC/CARBOPOL ON THE RELEASE OF CHLORPHENIRAMINE MALEATE FROM MATRIX TABLETS
    Patel, Bipin P.
    Patel, Dasharath M.
    Patel, Jayvadan K.
    INDONESIAN JOURNAL OF PHARMACY, 2013, 24 (03): : 157 - 162
  • [9] Effect of formulation variables on drug and polymer release from HPMC-based matrix tablets
    Sung, KC
    Nixon, PR
    Skoug, JW
    Ju, TR
    Gao, P
    Topp, EM
    Patel, MV
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 142 (01) : 53 - 60
  • [10] The effect of citric acid added to hydroxypropyl methylcellulose (HPMC) matrix tablets on the release of profile of vinpocetine
    Nie, SF
    Pan, WS
    Li, XD
    Wu, XM
    DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2004, 30 (06) : 627 - 635