Comprehensive evaluation of chiral pydiflumetofen from the perspective of reducing environmental risks

被引：25

作者：

Di, Shanshan ^{[1
,2
]}

Cang, Tao ^{[1
,2
]}

Liu, Zhenzhen ^{[1
,2
]}

Xie, Yunye ^{[3
]}

Zhao, Huiyu ^{[1
,2
]}

Qi, Peipei ^{[1
,2
]}

Wang, Zhiwei ^{[1
,2
]}

Xu, Hao ^{[1
,2
]}

Wang, Xinquan ^{[1
,2
,4
]}

机构：

[1] Zhejiang Acad Agr Sci, Inst Agroprod Safety & Nutr, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Detect Pesticide Residues & Control Zhejia, Hangzhou 310021, Peoples R China

[2] Agr Minist Key Lab Pesticide Residue Detect, Hangzhou 310021, Peoples R China

[3] Zhejiang Acad Agr Sci, Inst Plant Protect & Microbiol, Hangzhou 310021, Peoples R China

[4] Desheng Middle Rd 298, Hangzhou 310021, Zhejiang, Peoples R China

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2022年 / 826卷

基金：

中国国家自然科学基金;

关键词：

Pydiflumetofen enantiomers; Fungicidal activity; Toxicity; Enantioselective behaviors; Risk assessment; ENANTIOMERS; BEHAVIOR; PROGRESS;

D O I：

10.1016/j.scitotenv.2022.154033

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The spatial structures of chiral pesticide enantiomers can affect their activity, toxicity and behavior, thereby altering exposure risk. Identifying enantiomer differences and developing high-efficiency green enantiopure pesticide is an important strategy for reducing the negative effects of pesticides. In this study, after confirming the absolute configuration of pydiflumetofen enantiomers, fungicidal activity evaluation indicated that the activity of S-(+)-pydiflumetofen was 81.3-421 times higher than R-(-)-pydiflumetofen on three kinds of phytopathogens that control Fusarium wilt (Fusarium spp.), Alternaria rot (Alternaria alternata) and Southern blight (Sclerotinia rolfsii), which might be caused by the stronger binding ability of S-(+)-pydiflumetofen with the active site of the target protein. The coexistence of R-(-)-pydiflumetofen would enhance the toxicity of S-(+)-pydiflumetofen on zebrafish through synergistic effect. Low-activity R-(-)-pydiflumetofen was preferentially dissipated in soybean, soybean plants, cabbage and celery, which was opposite in soil. The persistence of S-(+)-pydiflumetofen in crops and degradability in soil were advantageous for pesticide effects and environmental protection. Based on the maximum residue limit (MRL) and hazard quotient (HQ), the dietary risks were determined to be acceptable for all crops. Thus, developing enantiopure S-(+)pydiflumetofen products might be a high-efficiency and low-risk strategy, and more studies should be conducted in this aspect.

引用

页数：9

共 31 条

[1]

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