Transcriptional Engineering of Microalgae: Prospects for High-Value Chemicals

被引:75
作者
Bajhaiya, Amit K. [1 ,2 ]
Moreira, Javiera Ziehe [1 ]
Pittman, Jon K. [1 ]
机构
[1] Univ Manchester, Fac Life Sci, Michael Smith Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England
[2] Umea Univ, Umea Plant Sci Ctr, Dept Plant Physiol, S-90187 Umea, Sweden
关键词
CHLAMYDOMONAS-REINHARDTII; LIPID-METABOLISM; EXPRESSION; REGULATOR;
D O I
10.1016/j.tibtech.2016.06.001
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Microalgae are diverse microorganisms that are of interest as novel sources of metabolites for various industrial, nutritional, and pharmaceutical applications. Recent studies have demonstrated transcriptional engineering of some metabolic pathways. We propose here that transcriptional engineering could be a viable means to manipulate the biosynthesis of specific high-value metabolic products.
引用
收藏
页码:95 / 99
页数:5
相关论文
共 13 条
[1]   PSR1 Is a Global Transcriptional Regulator of Phosphorus Deficiency Responses and Carbon Storage Metabolism in Chlamydomonas reinhardtii [J].
Bajhaiya, Amit K. ;
Dean, Andrew P. ;
Zeef, Leo A. H. ;
Webster, Rachel E. ;
Pittman, Jon K. .
PLANT PHYSIOLOGY, 2016, 170 (03) :1216-1234
[2]   Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors [J].
Butelli, Eugenio ;
Titta, Lucilla ;
Giorgio, Marco ;
Mock, Hans-Peter ;
Matros, Andrea ;
Peterek, Silke ;
Schijlen, Elio G. W. M. ;
Hall, Robert D. ;
Bovy, Arnaud G. ;
Luo, Jie ;
Martin, Cathie .
NATURE BIOTECHNOLOGY, 2008, 26 (11) :1301-1308
[3]   Identification of regulatory network hubs that control lipid metabolism in Chlamydomonas reinhardtii [J].
Gargouri, Mahmoud ;
Park, Jeong-Jin ;
Holguin, F. Omar ;
Kim, Min-Jeong ;
Wang, Hongxia ;
Deshpande, Rahul R. ;
Shachar-Hill, Yair ;
Hicks, Leslie M. ;
Gang, David R. .
JOURNAL OF EXPERIMENTAL BOTANY, 2015, 66 (15) :4551-4566
[4]   In Metabolic Engineering of Eukaryotic Microalgae: Potential and Challenges Come with Great Diversity [J].
Gimpel, Javier A. ;
Henriquez, Vitalia ;
Mayfield, Stephen P. .
FRONTIERS IN MICROBIOLOGY, 2015, 6
[5]  
Guamieri M. T., 2015, PHOTOSYNTH RES, V123, P255
[6]   Hypoosmotic Expression of Dunaliella bardawil ζ-Carotene Desaturase Is Attributed to a Hypoosmolarity-Responsive Element Different from Other Key Carotenogenic Genes [J].
Lao, Yong-Min ;
Xiao, Lan ;
Luo, Li-Xin ;
Jiang, Jian-Guo .
PLANT PHYSIOLOGY, 2014, 165 (01) :359-372
[7]   bZIP67 Regulates the Omega-3 Fatty Acid Content of Arabidopsis Seed Oil by Activating FATTY ACID DESATURASE3 [J].
Mendes, Ana ;
Kelly, Amelie A. ;
van Erp, Harrie ;
Shaw, Eve ;
Powers, Stephen J. ;
Kurup, Smita ;
Eastmond, Peter J. .
PLANT CELL, 2013, 25 (08) :3104-3116
[8]  
Ngan CY, 2015, NAT PLANTS, V1, DOI [10.1038/NPLANTS.2015.107, 10.1038/nplants.2015.107]
[9]   Regulation of Specialized Metabolism by WRKY Transcription Factors [J].
Schluttenhofer, Craig ;
Yuan, Ling .
PLANT PHYSIOLOGY, 2015, 167 (02) :295-306
[10]   Synthetic promoters capable of driving robust nuclear gene expression in the green alga Chlamydomonas reinhardtii [J].
Scranton, Melissa A. ;
Ostrand, Joseph T. ;
Georgianna, D. Ryan ;
Lofgren, Shane M. ;
Li, Daphne ;
Ellis, Rosalie C. ;
Carruthers, David N. ;
Draeger, Andreas ;
Masica, David L. ;
Mayfield, Stephen P. .
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, 2016, 15 :135-142