Immune Modulation of Stem Cells and Regeneration

被引：232

作者：

Aurora, Arin B. ^{[1
,2
]}

Olson, Eric N. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Ctr Regenerat Sci & Med, Dallas, TX 75390 USA

来源：

CELL STEM CELL | 2014年 / 15卷 / 01期

关键词：

ZEBRAFISH HEART REGENERATION; ACTIVATED MACROPHAGES; AXON REGENERATION; FACTOR-I; INFLAMMATION; MONOCYTES; INJURY; MOUSE; ANGIOGENESIS; HOMEOSTASIS;

D O I：

10.1016/j.stem.2014.06.009

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The immune system, best known as the first line of defense against invading pathogens, is integral to tissue development, homeostasis, and wound repair. In recent years, there has been a growing appreciation that cellular and humoral components of the immune system also contribute to regeneration of damaged tissues, including limbs, skeletal muscle, heart, and the nervous system. Here, we discuss key findings that implicate inflammatory cells and their secreted factors in tissue replacement after injury via stem cells and other reparative mechanisms. We highlight clinical conditions that are amenable to immune-mediated regeneration and suggest immune targeting strategies for tissue regeneration.

引用

页码：15 / 26

页数：12

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