Immune Modulation of Stem Cells and Regeneration

被引：232

作者：

Aurora, Arin B. ^{[1
,2
]}

Olson, Eric N. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Ctr Regenerat Sci & Med, Dallas, TX 75390 USA

来源：

CELL STEM CELL | 2014年 / 15卷 / 01期

关键词：

ZEBRAFISH HEART REGENERATION; ACTIVATED MACROPHAGES; AXON REGENERATION; FACTOR-I; INFLAMMATION; MONOCYTES; INJURY; MOUSE; ANGIOGENESIS; HOMEOSTASIS;

D O I：

10.1016/j.stem.2014.06.009

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The immune system, best known as the first line of defense against invading pathogens, is integral to tissue development, homeostasis, and wound repair. In recent years, there has been a growing appreciation that cellular and humoral components of the immune system also contribute to regeneration of damaged tissues, including limbs, skeletal muscle, heart, and the nervous system. Here, we discuss key findings that implicate inflammatory cells and their secreted factors in tissue replacement after injury via stem cells and other reparative mechanisms. We highlight clinical conditions that are amenable to immune-mediated regeneration and suggest immune targeting strategies for tissue regeneration.

引用

页码：15 / 26

页数：12

共 87 条

[1] Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis [J].

Arnold, Ludovic ;

Henry, Adeline ;

Poron, Francoise ;

Baba-Amer, Yasmine ;

van Rooijen, Nico ;

Plonquet, Anne ;

Gherardi, Romain K. ;

Chazaud, Benedicte .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (05) :1057-1069

[2] Macrophages are required for neonatal heart regeneration [J].

Aurora, Arin B. ;

Porrello, Enzo R. ;

Tan, Wei ;

Mahmoud, Ahmed I. ;

Hi, Joseph A. ;

Bassel-Duby, Rhonda ;

Sadek, Hesham A. ;

Olsonl, Eric N. .

JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (03) :1382-1392

[3] RETRACTED: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice (Retracted Article) [J].

Baeyens, Luc ;

Lemper, Marie ;

Leuckx, Gunter ;

De Groef, Sofie ;

Bonfanti, Paola ;

Stange, Geert ;

Shemer, Ruth ;

Nord, Christoffer ;

Scheel, David W. ;

Pan, Fong C. ;

Ahlgren, Ulf ;

Gu, Guoqiang ;

Stoffers, Doris A. ;

Dor, Yuval ;

Ferrer, Jorge ;

Gradwohl, Gerard ;

Wright, Christopher V. E. ;

Van de Casteele, Mark ;

German, Michael S. ;

Bouwens, Luc ;

Heimberg, Harry .

NATURE BIOTECHNOLOGY, 2014, 32 (01) :76-+

[4] Insulin cell mass is altered in Csf1op/Csf1op macrophage-deficient mice [J].

Banaei-Bouchareb, L ;

Gouon-Evans, V ;

Samara-Boustani, D ;

Castellotti, MC ;

Czernichow, P ;

Pollard, JW ;

Polak, M .

JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 76 (02) :359-367

[5] Requirement of myeloid cells for axon regeneration [J].

Barrette, Benoit ;

Hebert, Marc-Andre ;

Filali, Mohammed ;

Lafortune, Kathleen ;

Vallieres, Nicolas ;

Gowing, Genevieve ;

Julien, Jean-Pierre ;

Lacroix, Steve .

JOURNAL OF NEUROSCIENCE, 2008, 28 (38) :9363-9376

[6] Neuronal ER Stress Impedes Myeloid-Cell-Induced Vascular Regeneration through IRE1α Degradation of Netrin-1 [J].

Binet, Francois ;

Mawambo, Gaelle ;

Sitaras, Nicholas ;

Tetreault, Nicolas ;

Lapalme, Eric ;

Favret, Sandra ;

Cerani, Agustin ;

Leboeuf, Dominique ;

Tremblay, Sophie ;

Rezende, Flavio ;

Juan, Aimee M. ;

Stahl, Andreas ;

Joyal, Jean-Sebastien ;

Milot, Eric ;

Kaufman, Randal J. ;

Guimond, Martin ;

Kennedy, Timothy E. ;

Sapieha, Przemyslaw .

CELL METABOLISM, 2013, 17 (03) :353-371

[7] Thymosin β4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo [J].

Bock-Marquette, Ildiko ;

Shrivastava, Santwana ;

Pipes, G. C. Teg ;

Thatcher, Jeffrey E. ;

Blystone, Allissa ;

Shelton, John M. ;

Galindo, Cristi L. ;

Melegh, Bela ;

Srivastava, Deepak ;

Olson, Eric N. ;

DiMaio, J. Michael .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2009, 46 (05) :728-738

[8] Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease [J].

Boulter, Luke ;

Govaere, Olivier ;

Bird, Tom G. ;

Radulescu, Sorina ;

Ramachandran, Prakash ;

Pellicoro, Antonella ;

Ridgway, Rachel A. ;

Seo, Sang Soo ;

Spee, Bart ;

Van Rooijen, Nico ;

Sansom, Owen J. ;

Iredale, John P. ;

Lowell, Sally ;

Roskams, Tania ;

Forbes, Stuart J. .

NATURE MEDICINE, 2012, 18 (04) :572-579

[9] A Special Population of Regulatory T Cells Potentiates Muscle Repair [J].

Burzyn, Dalia ;

Kuswanto, Wilson ;

Kolodin, Dmitriy ;

Shadrach, Jennifer L. ;

Cerletti, Massimiliano ;

Jang, Young ;

Sefik, Esen ;

Tan, Tze Guan ;

Wagers, Amy J. ;

Benoist, Christophe ;

Mathis, Diane .

CELL, 2013, 155 (06) :1282-1295

[10] Immune Influence on Adult Neural Stem Cell Regulation and Function [J].

Carpentier, Pamela A. ;

Palmer, Theo D. .

NEURON, 2009, 64 (01) :79-92

← 1 2 3 4 5 6 7 8 9 →