Clostridium difficile infection in the twenty-first century

被引：76
作者：
Ghose, Chandrabali [1 ]
机构：
[1] Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA
来源：
EMERGING MICROBES & INFECTIONS | 2013年 / 2卷
关键词：
B1/NAP1/027; Clostridium difficile; fecal bacteriotherapy; monoclonal antibody; spore; toxin; vaccine; ANTIBIOTIC-ASSOCIATED DIARRHEA; TOXIN-B; SURFACE-PROTEINS; RISK-FACTOR; INTESTINAL COLONIZATION; NOSOCOMIAL ACQUISITION; MAJOR METABOLITE; IMMUNE-RESPONSE; FUSION PROTEIN; NORTH-AMERICA;
D O I：
10.1038/emi.2013.62
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Clostridium difficile is a spore-forming gram-positive bacillus, and the leading cause of antibiotic-associated nosocomial diarrhea and colitis in the industrialized world. With the emergence of a hypervirulent strain of C. difficile (BI/NAP1/027), the epidemiology of C. difficile infection has rapidly changed in the last decade. C. difficile infection, once thought to be an easy to treat bacterial infection, has evolved into an epidemic that is associated with a high rate of mortality, causing disease in patients thought to be low-risk. In this review, we discuss the changing face of C. difficile infection and the novel treatment and prevention strategies needed to halt this ever growing epidemic.
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页数：8
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