Sulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein Dishevelled

被引：74

作者：

Lee, Ho-Jin ^{[2
]}

Wang, Nick X. ^{[2
]}

Shi, De-Li ^{[1
]}

Zheng, Jie J. ^{[2
]}

机构：

[1] Univ Paris 06, Dev Biol Lab, F-75005 Paris, France

[2] St Jude Childrens Res Hosp, Dept Biol Struct, Memphis, TN 38105 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 35期

关键词：

antitumor agents; hydrogen bonds; signal inhibition; signal transduction; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; BETA-CATENIN; COLORECTAL-CANCER; EPIGENETIC INACTIVATION; HUMAN COUNTERPART; UP-REGULATION; NMR; TARGET; SULFONE; PATHWAY;

D O I：

10.1002/anie.200902981

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new application: The nonsteroidal anti-inflammatory drug sulindac interacts directly and specifically with the PDZ domain of the protein Dishevelled (Dvl), which is a key intracellular component of the Wnt signaling pathways. Sulindac binds to the conventional peptide-binding pocket of the domain (see picture), and may exert a cancer chemoprotective effect by blocking it, thereby inhibiting canonical Wnt signaling. © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.

引用

页码：6448 / 6452

页数：5

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