Immunocompromised and immunocompetent mouse models for head and neck squamous cell carcinoma

被引：35

作者：

Lei, Zhen-ge ^{[1
]}

Ren, Xiao-hua ^{[2
,3
]}

Wang, Sha-sha ^{[4
]}

Liang, Xin-hua ^{[4
,5
]}

Tang, Ya-ling ^{[4
,6
]}

机构：

[1] Nanchang Univ, Stomatol Hosp, Dept Oral & Maxillofacial Surg, Nanchang, Jiangxi, Peoples R China

[2] Sichuan Med Sci Acad, Dept Stomatol, Chengdu, Sichuan, Peoples R China

[3] Sichuan Prov Peoples Hosp, Chengdu, Sichuan, Peoples R China

[4] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, 14,Sect 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China

[5] Sichuan Univ, West China Coll Stomatol, Dept Oral & Maxillofacial Surg, 14,Sect 3,Renminnan Rd, Chengdu 610041, Sichuan, Peoples R China

[6] Sichuan Univ, West China Hosp Stomatol, Dept Oral Pathol, Chengdu 610041, Sichuan, Peoples R China

来源：

ONCOTARGETS AND THERAPY | 2016年 / 9卷

基金：

中国国家自然科学基金;

关键词：

head and neck squamous cell carcinoma; HNSCC; mouse models; immunocompromised models; immunocompetent models; transgenic models; PAPILLOMAVIRUS TYPE-16 E6; UPPER AERODIGESTIVE TRACT; GROWTH-FACTOR RECEPTOR; CANCER STEM-CELLS; TRANSGENIC MICE; MURINE MODEL; ORAL-CAVITY; IN-VITRO; ANIMAL-MODELS; K-RAS;

D O I：

10.2147/OTT.S95633

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Mouse models can closely mimic human oral squamous epithelial carcinogenesis, greatly expand the in vivo research possibilities, and play a critical role in the development of diagnosis, monitoring, and treatment of head and neck squamous cell carcinoma. With the development of the recent research on the contribution of immunity/inflammation to cancer initiation and progression, mouse models have been divided into two categories, namely, immunocompromised and immunocompetent mouse models. And thus, this paper will review these two kinds of models applied in head and neck squamous cell carcinoma to provide a platform to understand the complicated histological, molecular, and genetic changes of oral squamous epithelial tumorigenesis.

引用

页码：545 / 555

页数：11

共 141 条

[1] Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model [J].