Vibrational spectroscopy of betulinic acid HIV inhibitor and of its birch bark natural source

被引：38

作者：

Pînzaru, SC

Leopold, N

Kiefer, W

机构：

[1] Univ Babes Bolyai, Dept Phys, RO-3400 Cluj Napoca, Romania

[2] Univ Wurzburg, Inst Chem Phys, D-97074 Wurzburg, Germany

来源：

TALANTA | 2002年 / 57卷 / 04期

关键词：

betulinic acid; birch bark; Raman; SERS;

D O I：

10.1016/S0039-9140(02)00102-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Raman and IR spectra of betulinic acid (BA) (3beta-hydroxy-20(19) lupaen-28 oic acid) and of the natural birch bark have been successfully recorded and discussed. A high selectivity of the Raman technique was remarked for evidencing the betulin in the birch bark. Surface enhanced Raman spectrum (SERS) of BA on colloidal silver has been obtained. The presence and shifting of the symmetric stretching mode of the COO- group in the SERS spectrum suggests a chemisorption of the steroid structure on the metallic particles. (C) 2002 Elsevier Science B.V. All rights reserved.

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页码：625 / 631

页数：7

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