The role of the Xpert MTB/RIF assay among adolescents suspected of pulmonary tuberculosis in Rio de Janeiro, Brazil

被引：10

作者：

de Andrade Sieiro, Thania Luiza ^{[1
]}

Aurilio, Rafaela Baroni ^{[2
]}

Soares, Elizabeth Cristina C. ^{[3
]}

Chiang, Silvia S. ^{[4
]}

Sant' Anna, Clemax Couto ^{[5
,6
]}

机构：

[1] Secretaria Municipal Saude Nova Iguacu, Ctr Saude Vasco Barcelos, Nova Iguacu, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Inst Puericultura & Pediat Martagao Gesteira, Rio De Janeiro, RJ, Brazil

[3] Secretaria Municipal Saude Rio De Janeiro, Ctr Adm Sao Sebastiao, Rio De Janeiro, RJ, Brazil

[4] Brown Univ, Rhode Isl Hosp, Dept Pediat, Alpert Med Sch,Ctr Int Hlth Res, Providence, RI 02912 USA

[5] Univ Fed Rio de Janeiro, Fac Med, Dept Pediat, Rio De Janeiro, RJ, Brazil

[6] Rede Nacl Pesquisa Tb, Rede TB Pesquisa, Rio De Janeiro, RJ, Brazil

来源：

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2018年 / 51卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Tuberculosis; Adolescents; Polymerase chain reaction; IMPLEMENTATION; DIAGNOSIS; ACCURACY;

D O I：

10.1590/0037-8682-0298-2017

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The teste rapido molecular para tuberculose (TRM-TB) was introduced in 2014 in Brazil for tuberculosis screening. However, its role in adolescents in Brazil has not been studied. Methods: A descriptive study of adolescents with suspected tuberculosis using National Laboratory software. Results: Of 852 (15.4%) suspected cases, 131 were positive by TRM-TB and 2% were resistant to rifampicin. Among TRM-TB-positive cases. 105 (91.4%) were culture-positive. Sixty-four of 96 samples were sensitive to rifampicin by TRM-TB; 11 were resistant to other drugs by drug sensitivity test (DST). Conclusions: Among suspected cases, 16% were diagnosed by TRM-TB, of which 17% were drug-resistant by DST.

引用

页码：234 / 236

页数：3

共 15 条

[1] Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study [J].

Boehme, Catharina C. ;

Nicol, Mark P. ;

Nabeta, Pamela ;

Michael, Joy S. ;

Gotuzzo, Eduardo ;

Tahirli, Rasim ;

Gler, Ma Tarcela ;

Blakemore, Robert ;

Worodria, William ;

Gray, Christen ;

Huang, Laurence ;

Caceres, Tatiana ;

Mehdiyev, Rafail ;

Raymond, Lawrence ;

Whitelaw, Andrew ;

Sagadevan, Kalaiselvan ;

Alexander, Heather ;

Albert, Heidi ;

Cobelens, Frank ;

Cox, Helen ;

Alland, David ;

Perkins, Mark D. .

LANCET, 2011, 377 (9776) :1495-1505

[2]

Brasil Ministerio da Saude Secretaria de Vigila^ncia em Saude Departamento de Vigila^ncia Epidemiologica, 2011, MAN REC ES DIAGN OST

[3] Evaluation of Xpert® MTB/RIF Assay in Induced Sputum and Gastric Lavage Samples from Young Children with Suspected Tuberculosis from the MVA85A TB Vaccine Trial [J].

Bunyasi, Erick Wekesa ;

Tameris, Michele ;

Geldenhuys, Hennie ;

Schmidt, Bey-Marrie ;

Luabeya, Angelique Kany Kany ;

Mulenga, Humphrey ;

Scriba, Thomas J. ;

Hanekom, Willem A. ;

Mahomed, Hassan ;

McShane, Helen ;

Hatherill, Mark .

PLOS ONE, 2015, 10 (11)

[4] New Diagnostics for Childhood Tuberculosis [J].

Chiang, Silvia S. ;

Swanson, Douglas S. ;

Starke, Jeffrey R. .

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 2015, 29 (03) :477-+

[5] Impact of Replacing Smear Microscopy with Xpert MTB/RIF for Diagnosing Tuberculosis in Brazil: A Stepped-Wedge Cluster-Randomized Trial [J].

Durovni, Betina ;

Saraceni, Valeria ;

van den Hof, Susan ;

Trajman, Anete ;

Cordeiro-Santos, Marcelo ;

Cavalcante, Solange ;

Menezes, Alexandre ;

Cobelens, Frank .

PLOS MEDICINE, 2014, 11 (12)

[6]

Jesus R, 2013, EPIDEMIOL SERV SAUDE, V22, P525, DOI DOI 10.5123/S1679-49742013000300018

[7] Evaluation of Xpert MTB/RIF Versus AFB Smear and Culture to Identify Pulmonary Tuberculosis in Patients With Suspected Tuberculosis From Low and Higher Prevalence Settings [J].

Luetkemeyer, Anne F. ;

Firnhaber, Cynthia ;

Kendall, Michelle A. ;

Wu, Xingye ;

Mazurek, Gerald H. ;

Benator, Debra A. ;

Arduino, Roberto ;

Fernandez, Michel ;

Guy, Elizabeth ;

Johnson, Pamela ;

Metchock, Beverly ;

Sattler, Fred ;

Telzak, Edward ;

Wang, Yun F. ;

Weiner, Marc ;

Swindells, Susan ;

Sanne, Ian M. ;

Havlir, Diane V. ;

Grinsztejn, Beatriz ;

Alland, David .

CLINICAL INFECTIOUS DISEASES, 2016, 62 (09) :1081-1088

[8]

Ministerio da Saude (MS). Secretaria de Ciencia Tecnologia e Insumos Estrategicos. Comissao Nacional de Incorporacao de Tecnologias no SUS (CONITEC), 2013, SECR CIENC TECN INS

[9] Accuracy of the Xpert MTB/RIF test for the diagnosis of pulmonary tuberculosis in children admitted to hospital in Cape Town, South Africa: a descriptive study [J].

Nicol, Mark P. ;

Workman, Lesley ;

Isaacs, Washiefa ;

Munro, Jacinta ;

Black, Faye ;

Eley, Brian ;

Boehme, Catharina C. ;

Zemanay, Widaad ;

Zar, Heather J. .

LANCET INFECTIOUS DISEASES, 2011, 11 (11) :819-824

[10] Diagnostic Accuracy of GeneXpert MTB/RIF Assay in Comparison to Conventional Drug Susceptibility Testing Method for the Diagnosis of Multidrug-Resistant Tuberculosis [J].

Pandey, Pratikshya ;

Pant, Narayan Dutt ;

Rijal, Komal Raj ;

Shrestha, Bhawana ;

Kattel, Sirita ;

Banjara, Megha Raj ;

Maharjan, Bhagwan ;

Rajendra, K. C. .

PLOS ONE, 2017, 12 (01)

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