Current advancements and potential strategies in the development of MERS-CoV vaccines

被引：122
作者：
Zhang, Naru [1 ]
Jiang, Shibo [1 ,2 ,3 ,4 ]
Du, Lanying [1 ]
机构：
[1] New York Blood Ctr, Lindsley F Kimball Res Inst, New York, NY 10021 USA
[2] Fudan Univ, Minist Educ, Key Lab Med Mol Virol, Shanghai Med Coll, Shanghai 200433, Peoples R China
[3] Fudan Univ, Minist Hlth, Key Lab Med Mol Virol, Shanghai Med Coll, Shanghai 200433, Peoples R China
[4] Fudan Univ, Inst Med Microbiol, Shanghai 200433, Peoples R China
来源：
EXPERT REVIEW OF VACCINES | 2014年 / 13卷 / 06期
基金：
美国国家卫生研究院;
关键词：
adjuvants; administration routes; coronavirus; MERS-CoV; Middle East respiratory syndrome; receptor-binding domain; spike protein; subunit vaccines; vaccines; RESPIRATORY-SYNDROME CORONAVIRUS; RECEPTOR-BINDING DOMAIN; VIRUS-LIKE PARTICLES; MUCOSAL IMMUNE-RESPONSES; SPIKE PROTEIN; SARS-COV; S-PROTEIN; CRYSTAL-STRUCTURE; DNA VACCINE; INTRAMUSCULAR VACCINATION;
D O I：
10.1586/14760584.2014.912134
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Middle East respiratory syndrome (MERS) is a newly emerging infectious disease caused by a novel coronavirus, MERS-coronavirus (MERS-CoV), a new member in the lineage C of -coronavirus (-CoV). The increased human cases and high mortality rate of MERS-CoV infection make it essential to develop safe and effective vaccines. In this review, the current advancements and potential strategies in the development of MERS vaccines, particularly subunit vaccines based on MERS-CoV spike (S) protein and its receptor-binding domain (RBD), are discussed. How to improve the efficacy of subunit vaccines through novel adjuvant formulations and routes of administration as well as currently available animal models for evaluating the in vivo efficacy of MERS-CoV vaccines are also addressed. Overall, these strategies may have important implications for the development of effective and safe vaccines for MERS-CoV in the future.
引用
收藏
页码：761 / 774
页数：14
相关论文
共 128 条
[1]   Evaluation of Serologic and Antigenic Relationships Between Middle Eastern Respiratory Syndrome Coronavirus and Other Coronaviruses to Develop Vaccine Platforms for the Rapid Response to Emerging Coronaviruses [J].
Agnihothram, Sudhakar ;
Gopal, Robin ;
Yount, Boyd L., Jr. ;
Donaldson, Eric F. ;
Menachery, Vineet D. ;
Graham, Rachel L. ;
Scobey, Trevor D. ;
Gralinski, Lisa E. ;
Denison, Mark R. ;
Zambon, Maria ;
Baric, Ralph S. .
JOURNAL OF INFECTIOUS DISEASES, 2014, 209 (07) :995-1006
[2]   Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate [J].
Almazan, Fernando ;
DeDiego, Marta L. ;
Sola, Isabel ;
Zuniga, Sonia ;
Nieto-Torres, Jose L. ;
Marquez-Jurado, Silvia ;
Andres, German ;
Enjuanes, Luis .
MBIO, 2013, 4 (05)
[3]   The Importance of Adjuvant Formulation in the Development of a Tuberculosis Vaccine [J].
Baldwin, Susan L. ;
Bertholet, Sylvie ;
Reese, Valerie A. ;
Ching, Lance K. ;
Reed, Steven G. ;
Coler, Rhea N. .
JOURNAL OF IMMUNOLOGY, 2012, 188 (05) :2189-2197
[4]  
Balkhair Abdullah, 2013, Oman Med J, V28, P226, DOI 10.5001/omj.2013.66
[5]   Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice [J].
Bisht, H ;
Roberts, A ;
Vogel, L ;
Bukreyev, A ;
Collins, PL ;
Murphy, BR ;
Subbarao, K ;
Moss, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (17) :6641-6646
[6]   Identification of a receptor-binding domain of the spike glycoprotein of human coronavirus HCoV-229E [J].
Bonavia, A ;
Zelus, BD ;
Wentworth, DE ;
Talbot, PJ ;
Holmes, KV .
JOURNAL OF VIROLOGY, 2003, 77 (04) :2530-2538
[7]   Heterosubtypic cross-protection induced by whole inactivated influenza virus vaccine in mice: influence of the route of vaccine administration [J].
Budimir, Natalija ;
de Haan, Aalzen ;
Meijerhof, Tjarko ;
Gostick, Emma ;
Price, David A. ;
Huckriede, Anke ;
Wilschut, Jan .
INFLUENZA AND OTHER RESPIRATORY VIRUSES, 2013, 7 (06) :1202-1209
[8]   Mucosal immunisation of African green monkeys (Cercopithecus aethiops) with an attenuated parainfluenza virus expressing the SARS coronavirus spike protein for the prevention of SARS [J].
Bukreyev, A ;
Lamirande, EW ;
Buchholz, UJ ;
Vogel, LN ;
Elkins, WR ;
St Claire, M ;
Murphy, BR ;
Subbarao, K ;
Collins, PL .
LANCET, 2004, 363 (9427) :2122-2127
[9]   Potent and persistent antibody responses against the receptor-binding domain of SARS-CoV spike protein in recovered patients [J].
Cao, Zhiliang ;
Liu, Lifeng ;
Du, Lanying ;
Zhang, Chao ;
Jiang, Shibo ;
Li, Taisheng ;
He, Yuxian .
VIROLOGY JOURNAL, 2010, 7
[10]   The emerging novel Middle East respiratory syndrome coronavirus: The "knowns" and "unknowns" [J].
Chan, Jasper Fuk-Woo ;
Lau, Susanna Kar-Pui ;
Woo, Patrick Chiu-Yat .
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2013, 112 (07) :372-381
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