Fluorescent microspheres of poly(ethylene glycol)-poly(lactic acid)-fluorescein copolymers synthesized by Ugi four-component condensation

被引：12

作者：

Icart, Luis P. ^{[1
]}

Fernandes, Edson ^{[2
]}

Agueero, Lissette ^{[1
]}

Ramon, Jose ^{[1
]}

Zaldivar, Dionisio ^{[1
]}

Dias, Marcos L. ^{[3
]}

机构：

[1] Univ La Habana, Ctr Biomat, Havana, Cuba

[2] Univ Fed Rio de Janeiro, Ctr Tecnol, Escola Quim, Rio De Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, Inst Macromol Prof Eloisa Mano, Rio De Janeiro, Brazil

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2016年 / 133卷 / 09期

关键词：

biodegradable; biomedical applications; copolymers; drug-delivery systems; RING-OPENING POLYMERIZATION; PHOTOLUMINESCENCE QUANTUM YIELD; PLA; POLYLACTIDES; CDSE; ABSORPTION; HYDROGELS; POLYMERS; BEHAVIOR; RELEASE;

D O I：

10.1002/app.42994

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Microparticles formed by poly(lactic acid) (PLA) and poly(ethylene glycol) (PEG) diblock copolymers containing fluorescein grafted to the polymer chain were synthesized by a Ugi four-component condensation (UFCC) reaction. To synthesize these copolymers, lactide was first polymerized by a ring-opening polymerization with alcohol initiators containing functional groups to give carboxyl-and aldehyde-end-functionalized PLA. Two different fluorescent block copolymers (FCPs) of PEG-PLA conjugated to fluorescein (FCP 1 and FCP 2) were then synthesized by UFCC; they gave yields in the range 65-75%. These copolymers were characterized well according their chemical structures and thermal properties, and we prepared fluorescent microspheres (FMSs) from them with the single emulsion-solvent evaporation method (FMS 1 and FMS 2). A new application of UFCC in the preparation of biomasked drug-delivery systems is proposed. (C) 2015 Wiley Periodicals, Inc.

引用

页数：9

共 44 条

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