Efficient Route for Synthesis of Enamines from 1,3-Alkyl-2-Thioxodihydropyrimidine-4,6(1H,5H)-dione Enols

被引：0

作者：

Sharma, Anamika ^{[1
,2
]}

Almarhoon, Zainab M. ^{[3
]}

El-Faham, Ayman ^{[3
,4
]}

de la Torre, Beatriz G. ^{[5
]}

Albericio, Fernando ^{[2
,3
,6
,7
]}

机构：

[1] Univ KwaZulu Natal, Coll Hlth Sci, Sch Hlth Sci, Univ Rd, ZA-4000 Durban, South Africa

[2] Univ KwaZulu Natal, Sch Chem & Phys, Private Bag X54001,Westville Campus, ZA-4000 Durban, South Africa

[3] King Saud Univ, Dept Chem, Coll Sci, Riyadh 11451, Saudi Arabia

[4] Alexandria Univ, Dept Chem, Fac Sci, Alexandria 21321, Egypt

[5] Univ KwaZulu Natal, Coll Hlth Sci, KRISP, ZA-4001 Durban, South Africa

[6] Univ Barcelona, Dept Organ Chem, Marti i Franques 1-11, E-08028 Barcelona, Spain

[7] Networking Ctr Bioengn Biomat & Nanomed, CIBER BBN, Barcelona Sci Pk,Baldiri Reixac 10, Barcelona 08028, Spain

来源：

LETTERS IN ORGANIC CHEMISTRY | 2019年 / 16卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

Thiobarbituric acid; enols; enamines; greener approach; ammonium chloride; HPLC; HYDROGENATION; INHIBITORS; AGENTS;

D O I：

10.2174/1570178616666190409145118

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here we report a greener approach for the synthesis of enamines from enols of 1,3-alkyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione (thiobarbituric acid) acid using ammonium chloride and ethanol as solvents. This protocol removes the need for catalysts or harsh conditions.

引用

收藏

页码：538 / 540

页数：3

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