Xanthigen Attenuates High-fat Diet-induced Obesity through Down-regulation of PPARγ and Activation of the AMPK Pathway

被引：19

作者：

Choi, Kyeong-Mi ^{[1
]}

Jeon, Young Soo ^{[1
]}

Kim, Wonkyun ^{[1
]}

Lee, Anna ^{[1
]}

Kim, Yong-Gil ^{[1
]}

Lee, Ju Hyun ^{[1
]}

Kang, Young Eun ^{[1
]}

Jung, Jae-Chul ^{[2
]}

Lee, Jeongrai ^{[2
]}

Min, Bokkee ^{[2
]}

Kwon, Suk Hyung ^{[2
]}

Davis, Barbara ^{[3
]}

Lee, Mi Kyeong ^{[1
]}

Yoo, Hwan-Soo ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, Chungbuk, South Korea

[2] NOVAREX Co Ltd, Inst Life Sci, Ochang 363885, Chungbuk, South Korea

[3] PL Thomas & Co Inc, Morristown, NJ 07960 USA

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2014年 / 23卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Xanthigen; PPAR gamma; AMPK; leptin; obesity; PROTEIN-KINASE; ADIPOCYTE DIFFERENTIATION; INSULIN-RESISTANCE; CELLULAR-ENERGY; ADIPOGENESIS; FUCOXANTHIN; METABOLISM; MANAGEMENT; LEPTIN; SENSOR;

D O I：

10.1007/s10068-014-0125-1

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Xanthigen, a mixture of brown seaweed and pomegranate seed extracts, has weight loss properties and lipid-lowering effects in mice and humans. This study elucidated the Xanthigen mechanism of an anti-obesity activity in high-fat diet (HFD)-fed mice. Xanthigen decreased expression of peroxisome proliferator-activated receptor gamma (PPAR gamma) in the adipose tissue of HFD-fed mice. The serum leptin level and the adipose tissue leptin expression in mice fed HFD plus Xanthigen were significantly decreased, compared to HFD-fed mice. Phosphorylation of AMP-activated protein kinase (AMPK) alpha and beta and acetyl-CoA carboxylase (ACC) in the adipose tissue of HFD plus Xanthigen-fed mice was elevated, and HMG-CoA reductase (HMGCR) expression was decreased. Xanthigen may have an anti-obesity activity by down-regulation of PPAR gamma and activation of the AMPK pathway.

引用

页码：931 / 935

页数：5

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