Regulatory Principles of Pluripotency: From the Ground State Up

被引：290
作者：
Hackett, Jamie A. [1 ,2 ,3 ]
Surani, M. Azim [1 ,2 ,3 ]
机构：
[1] Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England
[2] Univ Cambridge, Wellcome Trust MRC Stem Cell Inst, Cambridge CB2 1QN, England
[3] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 1QN, England
来源：
CELL STEM CELL | 2014年 / 15卷 / 04期
基金：
英国惠康基金;
关键词：
EMBRYONIC STEM-CELLS; GENOMIC METHYLATION PATTERNS; SELF-RENEWAL; DNA METHYLATION; NAIVE PLURIPOTENCY; SIGNALING PATHWAYS; SYNERGISTIC ACTION; BETA-CATENIN; EPIBLAST; NANOG;
D O I：
10.1016/j.stem.2014.09.015
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Pluripotency is the remarkable capacity of a single cell to engender all the specialized cell types of an adult organism. This property can be captured indefinitely through derivation of self-renewing embryonic stem cells (ESCs), which represent an invaluable platform to investigate cell fate decisions and disease. Recent advances have revealed that manipulation of distinct signaling cues can render ESCs in a uniform "ground state" of pluripotency, which more closely recapitulates the pluripotent naive epiblast. Here we discuss the extrinsic and intrinsic regulatory principles that underpin the nature of pluripotency and consider the emerging spectrum of pluripotent states.
引用
收藏
页码：416 / 430
页数：15
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