Management of Prostate Cancer in the Elderly

被引：16

作者：

Tay, Kae Jack ^{[1
]}

Moul, Judd W. ^{[1
]}

Armstrong, Andrew J. ^{[2
]}

机构：

[1] Duke Univ, Div Urol, Med Ctr, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Med Oncol, Durham, NC 27710 USA

来源：

CLINICS IN GERIATRIC MEDICINE | 2016年 / 32卷 / 01期

关键词：

Prostate cancer; Elderly; Geriatric; Localized; Metastatic; Oncology; Surgery; Radiation; ANDROGEN-DEPRIVATION THERAPY; MITOXANTRONE PLUS PREDNISONE; OF-LIFE OUTCOMES; RADICAL PROSTATECTOMY; ACTIVE SURVEILLANCE; CONSERVATIVE MANAGEMENT; BIOCHEMICAL RECURRENCE; ABIRATERONE ACETATE; INCREASED SURVIVAL; NATURAL-HISTORY;

D O I：

10.1016/j.cger.2015.08.001

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The impact of localized prostate cancer in the elderly depends on disease aggressiveness and life expectancy. In men with localized prostate cancer, those with low-risk disease or a shorter life expectancy should be managed expectantly, whereas those with long life expectancy or more aggressive disease may benefit from curative treatment. Comorbidity and quality-of-life concerns are key considerations during the selection of therapeutic modalities in the elderly in localized and metastatic settings. A variety of new agents have changed the therapeutic landscape in castrate-resistant prostate cancer, but their benefits need to be considered alongside their side effects and cost.

引用

页码：113 / +

页数：21

共 117 条

[1] Delayed radical prostatectomy for intermediate-risk prostate cancer is associated with biochemical recurrence: Possible implications for active surveillance from the SEARCH database [J].