Cohort profile: Greifswald approach to individualized medicine (GANI_MED)

被引：35

作者：

Grabe, Hans J. ^{[1
]}

Assel, Heinrich ^{[2
]}

Bahls, Thomas ^{[3
,4
]}

Doerr, Marcus ^{[4
,5
]}

Endlich, Karlhans ^{[6
]}

Endlich, Nicole ^{[6
]}

Erdmann, Pia ^{[7
]}

Ewert, Ralf ^{[8
]}

Felix, Stephan B. ^{[4
,5
]}

Fiene, Beate ^{[9
]}

Fischer, Tobias ^{[10
]}

Flessa, Steffen ^{[11
]}

Friedrich, Nele ^{[4
,12
]}

Gadebusch-Bondio, Mariacarla ^{[10
,29
]}

Salazar, Manuela Gesell ^{[13
]}

Hammer, Elke ^{[4
,13
]}

Haring, Robin ^{[12
]}

Havemann, Christoph ^{[3
]}

Hecker, Michael ^{[14
]}

Hoffmann, Wolfgang ^{[3
,4
,7
]}

Holtfreter, Birte ^{[15
]}

Kacprowski, Tim ^{[13
]}

Klein, Kathleen ^{[16
]}

Kocher, Thomas ^{[15
]}

Kock, Holger ^{[17
]}

Krafczyk, Janina ^{[3
]}

Kuhn, Jana ^{[6
]}

Langanke, Martin ^{[2
]}

Lendeckel, Uwe ^{[18
]}

Lerch, Markus M. ^{[9
]}

Lieb, Wolfgang ^{[3
,30
]}

Lorbeer, Roberto ^{[3
]}

Mayerle, Julia ^{[9
]}

Meissner, Konrad ^{[19
]}

Schwabedissen, Henriette Meyer Zu ^{[16
,31
]}

Nauck, Matthias ^{[4
,12
]}

Ott, Konrad ^{[20
,32
]}

Rathmann, Wolfgang ^{[21
]}

Rettig, Rainer ^{[22
]}

Richardt, Claudia ^{[3
]}

Salje, Karen ^{[16
]}

Schminke, Ulf ^{[23
]}

Schulz, Andrea ^{[1
]}

Schwab, Matthias ^{[24
,25
]}

Siegmund, Werner ^{[16
]}

Stracke, Sylvia ^{[9
]}

Suhre, Karsten ^{[26
,33
]}

Ueffing, Marius ^{[27
,34
]}

Ungerer, Saskia ^{[23
]}

Voelker, Uwe ^{[4
,13
]}

机构：

[1] Univ Med Greifswald, Dept Psychiat & Psychotherapy, D-17475 Greifswald, Germany

[2] Univ Greifswald, Fac Theol, Greifswald, Germany

[3] Univ Med Greifswald, Inst Community Med, Greifswald, Germany

[4] Univ Med Greifswald, DZHK German Ctr Cardiovasc Res, Greifswald, Germany

[5] Univ Med Greifswald, Dept Internal Med B, Partner Site Greifswald, Greifswald, Germany

[6] Univ Med Greifswald, Inst Anat & Cell Biol, Greifswald, Germany

[7] Partner Site Rostock Greifswald, DZNE German Ctr Neurodegenerat Dis, Greifswald, Germany

[8] Univ Med Greifswald, Dept Internal Med, Greifswald, Germany

[9] Univ Med Greifswald, Dept Internal Med A, Greifswald, Germany

[10] Univ Med Greifswald, Inst Hist Med, Greifswald, Germany

[11] Univ Greifswald, Fac Law & Econ, Dept Hlth Care Management, Greifswald, Germany

[12] Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany

[13] Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany

[14] Univ Greifswald, Inst Microbiol, Greifswald, Germany

[15] Univ Med Greifswald, Dept Restorat Dent Periodontol & Endodontol, Greifswald, Germany

[16] Univ Med Greifswald, Dept Pharmacol, Greifswald, Germany

[17] Univ Med Greifswald, Greifswald, Germany

[18] Univ Med Greifswald, Inst Med Biochem & Mol Biol, Greifswald, Germany

[19] Univ Med Greifswald, Dept Anaesthesiol & Intens Care, Greifswald, Germany

[20] Univ Greifswald, Dept Philosophy, Greifswald, Germany

[21] Univ Dusseldorf, Inst Biometr & Epidemiol, German Diabet Ctr, Leibniz Ctr Diabet Res, Dusseldorf, Germany

[22] Univ Med Greifswald, Inst Physiol, Greifswald, Germany

[23] Univ Med Greifswald, Dept Neurol, Greifswald, Germany

[24] Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany

[25] Univ Tubingen Hosp, Dept Clin Pharmacol, Tubingen, Germany

[26] Helmholtz Zentrum, Inst Bioinformat & Syst Biol, Munich, Germany

[27] Helmholtz Zentrum, Resarch Unit Prot Sci, Munich, Germany

[28] Univ Med, Dept Obstet & Gynaecol, Greifswald, Germany

[29] Tech Univ Munich, Inst Hist & Eth Med, D-80290 Munich, Germany

[30] Univ Kiel, Inst Epidemiol, Kiel, Germany

[31] Univ Basel, Dept Pharmaceut Res, Basel, Switzerland

[32] Univ Kiel, Dept Philosophy, Kiel, Germany

[33] Weill Cornell Med Coll, Bioinformat Core, Doha, Qatar

[34] Univ Tubingen, Inst Ophthalm Res, Tubingen, Germany

[35] Univ Med Gottingen, Deans Off, Gottingen, Germany

来源：

JOURNAL OF TRANSLATIONAL MEDICINE | 2014年 / 12卷

关键词：

Personalized Medicine; Individualized Medicine; Epidemiology; HEALTH-CARE PROFESSIONALS; SERUM TOTAL TESTOSTERONE; ACUTE ISCHEMIC-STROKE; METABOLIC SYNDROME; HEART-FAILURE; EUROPEAN-SOCIETY; ALL-CAUSE; INDEX; ASSOCIATION; DIAGNOSIS;

D O I：

10.1186/1479-5876-12-144

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: Individualized Medicine aims at providing optimal treatment for an individual patient at a given time based on his specific genetic and molecular characteristics. This requires excellent clinical stratification of patients as well as the availability of genomic data and biomarkers as prerequisites for the development of novel diagnostic tools and therapeutic strategies. The University Medicine Greifswald, Germany, has launched the "Greifswald Approach to Individualized Medicine" (GANI_MED) project to address major challenges of Individualized Medicine. Herein, we describe the implementation of the scientific and clinical infrastructure that allows future translation of findings relevant to Individualized Medicine into clinical practice. Methods/design: Clinical patient cohorts (N > 5,000) with an emphasis on metabolic and cardiovascular diseases are being established following a standardized protocol for the assessment of medical history, laboratory biomarkers, and the collection of various biosamples for bio-banking purposes. A multi-omics based biomarker assessment including genome-wide genotyping, transcriptome, metabolome, and proteome analyses complements the multi-level approach of GANI_MED. Comparisons with the general background population as characterized by our Study of Health in Pomerania (SHIP) are performed. A central data management structure has been implemented to capture and integrate all relevant clinical data for research purposes. Ethical research projects on informed consent procedures, reporting of incidental findings, and economic evaluations were launched in parallel.

引用

页数：14

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