Emergent subtype of hepatitis E virus genotype 3 in wild boar in Spain

被引：23
作者：
Caballero-Gomez, Javier [1 ,2 ,3 ]
Jimenez-Ruiz, Saul [1 ,4 ,5 ]
Lopez-Lopez, Pedro [2 ,3 ]
Vicente, Joaquin [4 ,5 ]
Risalde, Maria A. [6 ]
Cano-Terriza, David [1 ]
Frias, Mario [2 ,3 ]
Barasona, Jose A. [4 ,5 ,7 ,8 ]
Rivero, Antonio [2 ,3 ]
Garcia-Bocanegra, Ignacio [1 ]
Rivero-Juarez, Antonio [2 ,3 ]
机构：
[1] Univ Cordoba, Anim Hlth Dept, Campus Univ Rabanales, Cordoba 14071, Spain
[2] Univ Cordoba, Maimonides Inst Biomed Res, Reina Sofia Hosp, Infect Dis Unit, Cordoba, Spain
[3] Univ Cordoba, Maimonides Inst Biomed Res, Reina Sofia Hosp, Clin Virol & Zoonoses Unit, Cordoba, Spain
[4] IREC, Spanish Wildlife Res Inst, Hlth & Biotechnol SaBio Grp, Ciudad Real, Spain
[5] CSIC, UCLM, JCCCM, Ciudad Real, Spain
[6] Univ Cordoba, Anim Pathol Dept, Cordoba, Spain
[7] Univ Complutense Madrid, VISAVET Ctr, Madrid, Spain
[8] Univ Complutense Madrid, Anim Hlth Dept, Vet Sch, Madrid, Spain
来源：
TRANSBOUNDARY AND EMERGING DISEASES | 2019年 / 66卷 / 05期
关键词：
genotype; 3; hepatitis E virus; public health; zoonosis; PREVALENCE; INFECTION; HUNTERS; DEER;
D O I：
10.1111/tbed.13251
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Wild boar (Sus scrofa) is considered as the main wildlife reservoir of zoonotic hepatitis E virus (HEV) genotypes. The aim of this study was to evaluate the circulation of HEV in free-ranging wild boar in the Donana National Park (DNP), Spain. Blood samples were collected from 99 wild boar in the DNP during 2015. Sera were analysed in parallel using indirect ELISA and real-time RT-PCR. A total of 57 of the 99 tested animals (57.6%; 95%CI: 47.8%-67.3%) had anti-HEV antibodies, indicating that this virus is widespread in wild boar in the DNP. HEV RNA was detected in one animal and phylogenetic analysis showed that the sequence isolated belonged to subtype 3r. The results suggest a potential risk of zoonotic transmission of this novel HEV-3 subtype, which could be of public health concern. Further studies are required to assess the role of wild boar in the epidemiology of HEV-3r and to determine the infectivity of this emergent HEV subtype in other species, including humans.
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收藏
页码：1803 / 1808
页数：6
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