Lauric acid and myristic acid prevent testosterone induced prostatic hyperplasia in rats

被引：72

作者：

Babu, S. V. Veeresh ^{[1
]}

Veeresh, B. ^{[1
]}

Patil, Anup A. ^{[1
]}

Warke, Y. B. ^{[1
]}

机构：

[1] KLESs Coll Pharm, Dept Pharmacol, Belgum, Karnataka, India

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2010年 / 626卷 / 2-3期

关键词：

Lauric acid; Myristic acid; Testosterone; Benign prostatic hyperplasia; 5-ALPHA-REDUCTASE ACTIVITY; DIHYDROTESTOSTERONE; INHIBITION;

D O I：

10.1016/j.ejphar.2009.09.037

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Numerous plants have proven to improve uncontrolled growth of the prostate gland and improve urinary tract symptoms associated with benign prostatic hyperplasia. Major components of those plants were lauric acid and myristic acid. Our study investigated whether lauric acid or myristic acid prevent testorsterone induced prostatic hyperplasia in rats. Rats were divided into negative control and testosterone induced prostatic hyperplasia rats (positive control, low dose lauric acid treated, high dose lauric acid treated, low dose of myristic acid treated, high dose of myristic acid treated, finasteride treated). Testosterone and drug treatment were carried out for 14 days. Body weights were recorded before and after treatment. On 15th day, rats were sacrificed, prostates were weighed and histopathological studies were carried out. Lauric acid/myristic acid treatment showed significant inhibition of prostate enlargement and protection of histoarchitecture of prostate when compared with positive control group. In conclusion, the study showed that lauric acid/myristic acid reduced the increase of both prostate weight and prostate weight:body weight ratio, markers of testosterone induced prostatic hyperplasia in rats. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：262 / 265

页数：4

共 20 条

[1]

ALIAEV LG, 2002, UROLOGIA, V1, P23

[2] Effects of coconut oil on testosterone-induced prostatic hyperplasia in Sprague-Dawley rats [J].

Arruzazabala, Maria de Lourdes ;

Molina, Vivian ;

Mas, Rosa ;

Carbajal, Daisy ;

Marrero, David ;

Gonzalez, Victor ;

Rodriguez, Eduardo .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 2007, 59 (07) :995-999

[3] Evaluation of symptoms and quality of life in men with benign prostatic hyperplasia [J].

Barry, MJ .

UROLOGY, 2001, 58 (6A) :25-32

[4] Dihydrotestosterone and the concept of 5α-reductase inhibition in human benign prostatic hyperplasia [J].

Bartsch, G ;

Rittmaster, RS ;

Klocker, H .

EUROPEAN UROLOGY, 2000, 37 (04) :367-380

[5] Effects of D-004, a lipid extract from Cuban Royal palm fruit, on inhibiting prostatic hypertrophy induced with testosterone or dihydrotestosterone in a rat model:: A randomized, controlled study [J].

Carbajal, D ;

Arruzazabala, MD ;

Más, R ;

Molina, V ;

Rodríguez, E ;

González, V .

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 2004, 65 (06) :505-514

[6] The role of dihydrotestosterone in benign prostatic hyperplasia [J].

Carson, C ;

Rittmaster, R .

UROLOGY, 2003, 61 (04) :2-7

[7] BENIGN PROSTATIC HYPERPLASIA - PATHOGENESIS AND MEDICAL THERAPY [J].

GELLER, J .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1991, 39 (12) :1208-1216

[8]

Gossel TA., 2004, Contin Educ Pharm, V22, P1

[9] INHIBITION OF STEROID 5-ALPHA-REDUCTASE BY SPECIFIC ALIPHATIC UNSATURATED FATTY-ACIDS [J].

LIANG, TM ;

LIAO, SS .

BIOCHEMICAL JOURNAL, 1992, 285 :557-562

[10]

Lowe FC, 1998, PROSTATE, V37, P187

← 1 2 →