Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells

被引：14

作者：

Hosokawa, Yoshitaka ^{[1
]}

Hosokawa, Ikuko ^{[1
]}

Shindo, Satoru ^{[1
]}

Ozaki, Kazumi ^{[2
]}

Matsuo, Takashi ^{[1
]}

机构：

[1] Univ Tokushima, Grad Sch, Inst Biomed Sci, Dept Conservat Dent, 3-18-15 Kuramoto Cho, Tokushima, Tokushima 7708504, Japan

[2] Univ Tokushima, Grad Sch, Inst Biomed Sci, Dept Oral Hlth Care Promot, Tokushima, Tokushima, Japan

来源：

INFLAMMATION | 2017年 / 40卷 / 02期

关键词：

gomisin N; inflammatory cytokine; MAPKs; periodontal ligament cells; SCHISANDRA-CHINENSIS; TH17; CELLS; DISEASE; INVOLVEMENT; ACTIVATION;

D O I：

10.1007/s10753-016-0482-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Gomisin N, which is a lignan isolated from Schisandra chinensis, has some pharmacological effects. However, the anti-inflammatory effects of gomisin N on periodontal disease are uncertain. The aim of this study was to examine the effect of gomisin N on inflammatory mediator production in tumor necrosis factor (TNF)-alpha-stimulated human periodontal ligament cells (HPDLC). Gomisin N inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 2, and CCL20 production in TNF-alpha-stimulated HPDLC in a dose-dependent manner. Moreover, we revealed that gomisin N could suppress extracellular signal-regulated kinase (ERK) and c-Jun N terminal kinase (JNK) phosphorylation in TNF-alpha-stimulated HPDLC though protein kinase B (Akt) phosphorylation was not suppressed by gomisin N treatment. In summary, gomisin N might exert anti-inflammatory effects by attenuating cytokine production in periodontal ligament cells via inhibiting the TNF-alpha-stimulated ERK and JNK pathways activation.

引用

页码：360 / 365

页数：6

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