So do we understand how enzymes work?

被引：53

作者：

Blow, D ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Blackett Lab, London SW7 2BZ, England

来源：

STRUCTURE WITH FOLDING & DESIGN | 2000年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0969-2126(00)00125-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Between 1930 and 1975 biochemical and structural analysis of enzymes led to a clear set of ideas that might form a basis for detailed understanding of enzyme action, Further development required energetic and thermodynamic analysis of enzymes in an aqueous medium, beyond the computational power then available, Structural enzymology advanced in other directions, but the fundamental questions of enzyme action must soon be re-opened.

引用

页码：R77 / R81

页数：5

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