Osteogenic abilities of bone marrow stromal cells are not defective in patients with osteonecrosis

被引：19
|
作者：
Yoo, Jeong Joon [4 ]
Song, Won Seok [3 ]
Koo, Kyung-Hoi [4 ]
Yoon, Kang Sup [4 ]
Kim, Hee Joong [1 ,2 ,4 ]
机构：
[1] Seoul Natl Univ Hosp, Dept Orthopaed Surg, Seoul 110744, South Korea
[2] Seoul Natl Univ, Med Res Ctr, Seoul, South Korea
[3] Korea Canc Ctr Hosp, Dept Orthopaed Surg, Seoul, South Korea
[4] Seoul Natl Univ, Coll Med, Dept Orthopaed Surg, Seoul, South Korea
来源：
INTERNATIONAL ORTHOPAEDICS | 2009年 / 33卷 / 03期
关键词：
MESENCHYMAL STEM-CELLS; FEMORAL-HEAD; AVASCULAR NECROSIS; ILIAC CREST; INDUCED ADIPOGENESIS; FAT; DIFFERENTIATION; MECHANISM; DECREASE; HIP;
D O I：
10.1007/s00264-008-0524-0
中图分类号：
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];
学科分类号：
摘要：
We investigated whether the proliferation activities and osteogenic capacities of bone marrow stromal cells (BMSCs) are depressed in patients with osteonecrosis of the femoral head (ONFH). BMSCs were isolated from fresh bone marrow of the iliac crests of 54 donors and were differentiated into osteogenic lineage in vitro. The results of 27 consecutive patients with ONFH (16 idiopathic and 11 alcohol-induced) were compared with those of 27 patients with a nonnecrotic hip disorder. The proliferative activities of BMSCs in patients with ONFH were not found to be reduced and their osteogenic capacities (alkaline phosphatase activity and calcium deposition amount) were unaltered during in vitro differentiation. Results from patients with idiopathic or alcohol-induced ONFH were similar to those of matched patients with nonnecrotic disorder. These findings suggest that the osteogenic potentials of BMSCs are not defective in patients with ONFH.
引用
收藏
页码：867 / 872
页数：6
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