The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity

被引：67

作者：

Reinhold, D

Kähne, T

Steinbrecher, A

Wrenger, S

Neubert, K

Ansorge, S

Brocke, S

机构：

[1] Univ Magdeburg, Inst Immunol, D-39120 Magdeburg, Germany

[2] Univ Magdeburg, Inst Expt Internal Med, D-39120 Magdeburg, Germany

[3] Univ Regensburg, Dept Neurol, D-93053 Regensburg, Germany

[4] Univ Halle Wittenberg, Inst Biochem, Dept Biochem & Biotechnol, D-61120 Halle An Der Saale, Saale, Germany

[5] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Pathol, IL-91120 Jerusalem, Israel

来源：

BIOLOGICAL CHEMISTRY | 2002年 / 383卷 / 7-8期

关键词：

autoimmune diseases; CD26; dipeptidyl peptidase IV; T cell activation;

D O I：

10.1515/BC.2002.123

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activated T lymphocytes express high levels of dipeptidyl peptidase IV (DP IV)/CD26. Recent studies support the notion that DP IV may play an important role in the regulation of differentiation and growth of T lymphocytes. This article gives a short overview on DP IV/CD26 expression and effects on immune cells in vitro and in vivo. A major focus of this review are clinical aspects of the function of CD26 on hematopoietic cells and the potential usage of synthetic DP IV inhibitors as therapeutics in inflammatory disorders.

引用

页码：1133 / 1138

页数：6

共 35 条

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