Copper-Catalyzed Regio- and Stereoselective Oxidative Vinylsulfonylation of Quinoxalinones with Alkynes and Sulfonyl Hydrazides

被引：25

作者：

Clinton, Chayan Dhar ^{[1
]}

Prasad, Ch. Durga ^{[1
]}

Thombal, Raju S. ^{[1
]}

Lee, Yong Rok ^{[1
]}

机构：

[1] Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, South Korea

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2021年 / 363卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Quinoxalinones; Vinylsulfonylation; Radical; Alkynes; Peroxide; VINYL SULFONES; QUINOXALIN-2(1H)-ONES; ARYLATION; ALKENES; INHIBITORS; SULFONYLHYDRAZIDES; ESTERIFICATION; ALDEHYDES; ALCOHOLS; DIOXYGEN;

D O I：

10.1002/adsc.202001182

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient approach to regio- and stereoselective synthesis of (Z)-vinylsulfonylated quinoxalin-2-ones has been developed. This oxidative reaction involves copper-catalyzed vinylsulfonylation of quinoxalin-2(1H)-ones with alkynes and sulfonyl hydrazides. Various functionalized vinylsulfonylated quinoxalin-2(1H)-one derivatives have been synthesized in excellent yields. The reaction proceeds via sulfonyl radicals generated from sulfonyl hydrazides.

引用

页码：776 / 784

页数：9

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