[18F]-dopa positron emission tomography imaging in early-stage, non-parkin juvenile parkinsonism

被引：11

作者：

Pal, PK

Leung, J

Hedrich, K

Samii, A

Lieberman, A

Nausieda, PA

Calne, DB

Breakefield, XO

Klein, C

Stoessl, AJ

机构：

[1] Univ British Columbia, Vancouver Hosp, Ctr Neurodegenerat Disorders, Vancouver, BC V6T 2B5, Canada

[2] Univ British Columbia, Hlth Sci Ctr, Ctr Neurodegenerat Disorders, Vancouver, BC V6T 2B5, Canada

[3] Massachusetts Gen Hosp, Dept Neurol, Mol Neurogenet Unit, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] Med Univ Lubeck, Dept Neurol, D-23538 Lubeck, Germany

[6] Med Univ Lubeck, Dept Human Genet, D-23538 Lubeck, Germany

[7] Natl Parkinson Fdn, Miami, FL USA

[8] St Josephs Hosp, NPF Ctr Excellence, Milwaukee, WI USA

来源：

MOVEMENT DISORDERS | 2002年 / 17卷 / 04期

关键词：

parkin; dopamine; Parkinson's disease; PET; genetics;

D O I：

10.1002/mds.10133

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

There are few reports of positron emission tomography (PET) in juvenile parkinsonism (JP). We report on the results of F-18-6-fluoro-L-dopa (FD) PET in a 14-year-old patient with JP of 5 years duration associated with atypical features. This is the youngest subject to be investigated to date. There was a severe asymmetric reduction in striatal FD uptake, with a rostrocaudal gradient in the putamen similar to that seen in adult-onset idiopathic parkinsonism. Extensive DNA analysis in this patient did not show mutations in the Parkin gene. (C) 2002 Movement Disorder Society.

引用

收藏

页码：789 / 794

页数：6

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