Palladium-Catalyzed Asymmetric Ring Opening Reaction of Azabenzonorbornadienes with Aromatic Amines

被引：40
|
作者：
Lu, Zhiwu [1 ]
Wang, Jun [2 ]
Han, Baiqiu [1 ]
Li, Sifeng [2 ]
Zhou, Yongyun [1 ]
Fan, Baomin [1 ,3 ]
机构：
[1] Yunnan Minzu Univ, YMU HKBU Joint Lab Tradit Nat Med, Kunming 650500, Peoples R China
[2] South Univ Sci & Technol China, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China
[3] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 14-15期
基金：
中国国家自然科学基金;
关键词：
amines; asymmetric ring opening reaction; azabenzonorbornadienes; palladium; silver; N-BOC-AZABENZONORBORNADIENE; SUBSTITUTED PIPERAZINE NUCLEOPHILES; ENANTIOSELECTIVE EPOXIDATION; AZABICYCLIC ALKENES; OXABENZONORBORNADIENES; LIGANDS; ANALOGS;
D O I：
10.1002/adsc.201500530
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A palladium/(R)-Binap catalyst for asymmetric ring opening reaction of azabenzonorbornadienes with amines was developed that afforded the corresponding substituted dihydronaphthalenes in good yields (up to 97%) with excellent enantioselectivities (up to > 99% ee). To the best of our knowledge, this represents the first palladium-catalyzed asymmetric ring opening reaction of azabenzonorbornadienes with heteronucleophiles.
引用
收藏
页码：3121 / 3125
页数：5
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