Short, but Smart: SCFAs Train T Cells in the Gut to Fight Autoimmunity in the Brain

被引：74

作者：

Bhutia, Yangzom D. ^{[1
]}

Ganapathy, Vadivel ^{[1
]}

机构：

[1] Texas Tech Univ, Hlth Sci Ctr, Dept Cell Biol & Biochem, Lubbock, TX 79430 USA

来源：

IMMUNITY | 2015年 / 43卷 / 04期

关键词：

CHAIN FATTY-ACIDS; TRANSPORTER; MICROBIOTA;

D O I：

10.1016/j.immuni.2015.09.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this issue of Immunity, Haghikia and colleagues (2015) demonstrate that dietary fatty acids, by modulating gut microbes and their metabolism, regulate mucosal immune cells to impact systemic immunity. Using this mechanism, dietary and bacteria-derived medium-chain and long-chain fatty acids exacerbate, whereas short-chain fatty acids ameliorate, autoimmunity in the brain.

引用

页码：629 / 631

页数：3

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