Synthesis and Antibacterial Evaluation of Carboxamide Derivatives of Amino Acids

被引：9

作者：

Pande, S. V. ^{[1
]}

Utale, P. S. ^{[2
]}

Gholse, S. B. ^{[1
]}

Tekade, P. V. ^{[3
]}

Patil, S. G. ^{[1
]}

机构：

[1] Nagpur Univ, Laxminarayan Inst Technol, Dept Chem, Nagpur 440010, Maharashtra, India

[2] Shri Shivaji Sci Coll, Dept Chem, Nagpur, Maharashtra, India

[3] Jankidevi Bajaj Coll Sci, Dept Chem, Wardha, Maharashtra, India

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2014年 / 48卷 / 01期

关键词：

carboxamide; cycloalkylamine; antibacterial activity; amino acid; INHIBITORS;

D O I：

10.1007/s11094-014-1040-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of carboxamide derivatives of amino acids were synthesized, characterized and their antibacterial properties were evaluated. These compounds were synthesized by reaction of cycloalkylamine with N-phthaloyl amino acids and characterized using IR, H-1-NMR, and mass spectroscopy. The synthesized compounds were screened for their in vitro antibacterial activity against bacteria S. aureus, E. coli, P. aeruginosa and S. typhimurium Some of these compounds exhibited moderate to good activity, whereas some were inactive.

引用

页码：29 / 33

页数：5

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