Alcohol-Directed ortho -C-H Alkenylation

被引：4

作者：

Li, Li ^{[1
]}

Liu, Qinglan ^{[1
]}

Chen, Jiean ^{[1
]}

Huang, Yong ^{[1
]}

机构：

[1] Peking Univ, Shenzhen Grad Sch, Key Lab Chem Genom, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China

来源：

SYNLETT | 2019年 / 30卷 / 11期

基金：

中国国家自然科学基金;

关键词：

directing group; palladium catalysis; cross-coupling; C-H activation; arylethanols; acrylates; FUNCTIONALIZATION; BOND; ACTIVATION; CYCLIZATION; CATALYSIS; HYDROXYL; SILANOL; ACETOXYLATION; 2-ARYLPHENOLS; DIBENZOFURANS;

D O I：

10.1055/s-0037-1611538

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report a simple and mild dehydrogenative cross-coupling reaction of unprotected arylethanols and acrylates. Unlike the case of previous reactions, in which prior functionalization of the substrate with a metal-coordinating site was required, free primary, secondary, or tertiary hydroxy groups were found to be effective directing groups for the ortho -C-H palladation and subsequent olefination.

引用

页码：1366 / 1370

页数：5

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