Alcohol-Directed ortho -C-H Alkenylation

被引：4
|
作者：
Li, Li [1 ]
Liu, Qinglan [1 ]
Chen, Jiean [1 ]
Huang, Yong [1 ]
机构：
[1] Peking Univ, Shenzhen Grad Sch, Key Lab Chem Genom, State Key Lab Chem Oncogen, Shenzhen 518055, Peoples R China
来源：
SYNLETT | 2019年 / 30卷 / 11期
基金：
中国国家自然科学基金;
关键词：
directing group; palladium catalysis; cross-coupling; C-H activation; arylethanols; acrylates; FUNCTIONALIZATION; BOND; ACTIVATION; CYCLIZATION; CATALYSIS; HYDROXYL; SILANOL; ACETOXYLATION; 2-ARYLPHENOLS; DIBENZOFURANS;
D O I：
10.1055/s-0037-1611538
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report a simple and mild dehydrogenative cross-coupling reaction of unprotected arylethanols and acrylates. Unlike the case of previous reactions, in which prior functionalization of the substrate with a metal-coordinating site was required, free primary, secondary, or tertiary hydroxy groups were found to be effective directing groups for the ortho -C-H palladation and subsequent olefination.
引用
收藏
页码：1366 / 1370
页数：5
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