"Self-activating" chemical nuclease: Ferrocenyl cyclen Cu(II) complexes act as efficient DNA cleavage reagents in the absence of reductant

被引：31

作者：

Li, Kun ^{[1
]}

Zhou, Li-Hong ^{[1
]}

Zhang, Ji ^{[1
]}

Chen, Shan-Yong ^{[1
]}

Zhang, Zhong-Wei ^{[2
]}

Zhang, Jing-Jing ^{[1
]}

Lin, Hong-Hui ^{[2
]}

Yu, Xiao-Qi ^{[1
,3
]}

机构：

[1] Sichuan Univ, Minist Educ, Dept Chem, Key Lab Green Chem & Technol, Chengdu 610064, Sichuan, Peoples R China

[2] Sichuan Univ, Coll Life Sci, Minist Educ, Key Lab Bioresources & Ecoenvironm, Chengdu 610064, Sichuan, Peoples R China

[3] Sichuan Univ, W China Med Sch, W China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 04期

基金：

美国国家科学基金会;

关键词：

Chemical nucleases; DNA cleavage; Cyclen; Complexes; MACROCYCLIC POLYAMINE ZINC(II); TRINUCLEAR COPPER(II) COMPLEX; PLASMID DNA; ANTIMALARIAL ACTIVITY; STRAND BREAKS; IN-VITRO; CHLOROQUINE; OXYGEN; NADH; AFFINITY;

D O I：

10.1016/j.ejmech.2008.03.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The interactions of cyclen Cu(II) complexes functionalized by ferrocenyl group with plasmid DNA indicated that these complexes have high cleavage efficiency via an oxidative mechanism in the absence of any reductant or oxidant. (c) 2008 Elsevier Masson SAS. All fights reserved.

引用

页码：1768 / 1772

页数：5

共 41 条

[1] Photochemistry of N-isopropoxy-substituted 2(1H)-pyridone and 4-p-tolylthiazole-2(3H)-thione:: Alkoxyl-radical release (spin-trapping, EPR, and transient spectroscopy) and its significance in the photooxidative induction of DNA strand breaks [J].