Assessment of Conjugal Transfer of Antibiotic Resistance Genes in Salmonella Typhimurium Exposed to Bile Salts

被引：6

作者：

He, Xinlong ^{[1
]}

Ahn, Juhee ^{[1
]}

机构：

[1] Kangwon Natl Univ, Dept Med Biomat Engn, Chunchon 200701, South Korea

来源：

JOURNAL OF MICROBIOLOGY | 2014年 / 52卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

Salmonella Typhimurium; antibiotic resistance; virulence; gene transfer; bile salt; ANTIMICROBIAL RESISTANCE; BACTERIAL CONJUGATION; PLASMID; INTEGRONS; CASSETTES; VIRULENCE; EXPRESSION; ANIMALS;

D O I：

10.1007/s12275-014-3340-9

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study was designed to evaluate the transfer potential of antibiotic resistance genes in antibiotic-resistant Salmonella Typhimurium (S. Typhimurium(R)) in the presence of bile salts. The resistance of S. Typhimurium(R) to ampicillin, kanamycin, and tetracycline was increased by 64-, 64-, and 512-fold, respectively. The highest transfer frequency from S. Typhimurium(R) to Escherichia colt was observed at the bile salt concentration of 160 mu g/ml (3.8 x 10(-3) transferrants/cells). The expression of traJ and traY was suppressed in S. Typhimurium(R) by bile salt. This study provides useful information for understanding the conjugative transfer of antibiotic resistance genes in S. Typhimurium under intestinal conditions.

引用

页码：716 / 719

页数：4

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