Formulation and In Vitro Evaluation of Sumatriptane Succinate Transdermal Patches

The aim of the present research was to develop and evaluate transdermal patch formulations of Sumatriptan Succinate (SUS). Matrix type transdermal patches of SUS were prepared by solvent evaporation technique. The enhancing effects of the permeation enhancers Tween 80 (0.25, 0.5,1, 1.5 and 2% w/w), olive oil (2, 4, 6, 8 and 10% w/w) and Isopropyl myristate (2, 4, 6, 8 and 10% w/w IPM) were evaluated using Franz diffusion cell and rabbit skin membrane. All the formulations were subjected to physical (rheological) and in vitro permeation studies. IPM (10%) showed 2-fold enhancement in permeation compared to the control formulation (without enhancer) and also greater permeability was noticed compared to Tween 80 and olive oil. In conclusion, the present data confirm the feasibility of developing SUS transdermal patches.