The impact of single-cell RNA sequencing on understanding the functional organization of the immune system

被引：16
|
作者：
Vegh, Peter [1 ]
Haniffa, Muzlifah [1 ]
机构：
[1] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
来源：
BRIEFINGS IN FUNCTIONAL GENOMICS | 2018年 / 17卷 / 04期
基金：
英国惠康基金;
关键词：
RNA-seq; single-cell; monocyte; macrophage; dendritic cell; lymphocyte; INNATE LYMPHOID-CELLS; GENE-EXPRESSION DATA; REGULATORY NETWORK INFERENCE; T-CELLS; TRANSCRIPTIONAL HETEROGENEITY; HIGH-THROUGHPUT; SEQ DATA; HI-C; DIFFERENTIATION; PROGENITOR;
D O I：
10.1093/bfgp/ely003
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Application of single-cell genomics technologies has revolutionized our approach to study the immune system. Unravelling the functional diversity of immune cells and their coordinated response is key to understanding immunity. Single-cell transcriptomics technologies provide high-dimensional assessment of the transcriptional states of immune cells and have been successfully applied to discover new immune cell types, reveal haematopoietic lineages, identify gene modules dictating immune responses and investigate lymphocyte antigen receptor diversity. In this review, we discuss the impact and applications of single-cell RNA sequencing technologies in immunology.
引用
收藏
页码：265 / 272
页数：8
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