Morphology design and control of polymer particles by regulating the droplet flowing mode in microfluidic chips

被引：10

作者：

Chen, Rui ^{[1
]}

Chen, Xiang ^{[2
]}

Jin, Xin ^{[1
]}

Zhu, Xinyuan ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Natl Key Lab Sci & Technol Micro Nano Fabricat, Dept Micro Nano Elect, Shanghai 200240, Peoples R China

来源：

POLYMER CHEMISTRY | 2017年 / 8卷 / 19期

基金：

中国国家自然科学基金;

关键词：

GENERATION; MICROGELS; DELIVERY; SHELL;

D O I：

10.1039/c7py00440k

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this work, a new strategy for morphology design and control of polymer particles was developed by regulating the droplet flowing mode in microfluidic chips. Firstly, a simple droplet microfluidic chip was manufactured successfully with the help of three dimensional (3D) printing, which was used to control the morphology of polymer particles. According to their diameter, droplets adopted two types of flowing modes: confining mode and rolling mode. Rod-like droplets were formed in confining mode, while ellipsoid droplets were formed in rolling mode. After solidification of droplets, polymer particles with different morphologies could be obtained. Factors such as velocity, viscosity, and interfacial tension that could affect the flowing mode were studied systematically. Based on this strategy, the aspect ratio of rod-like and ellipsoid polymer particles could be changed simply and more hierarchical morphologies such as hollow-sphere particles can be easily prepared.

引用

页码：2953 / 2958

页数：6

共 27 条

[1] Biofunctionalized magnetic nanospheres-based cell sorting strategy for efficient isolation, detection and subtype analyses of heterogeneous circulating hepatocellular carcinoma cells [J].