Progressive epigenetic dysregulation in neuroendocrine tumour liver metastases

被引：38

作者：

Karpahakis, Anna ^{[1
,2
]}

Dibra, Ilarpreet ^{[1
]}

Pipinikas, Christodoulos ^{[1
]}

Feber, Andrew ^{[1
]}

Morris, Tiffany ^{[1
]}

Francis, Joshua ^{[3
]}

Oukrif, Dahmane ^{[1
]}

Mandair, Dalvinder ^{[1
,2
]}

Pericleous, Marinas ^{[2
]}

Mohmaduvesh, Mullan ^{[2
]}

Serra, Stefano ^{[4
]}

Ogunbiyi, Olagunju ^{[2
]}

Novelli, Marco ^{[1
]}

Luong, TuVinh ^{[2
]}

Asa, Sylvia L. ^{[4
]}

Kulke, Matthew ^{[5
]}

Tourripanakis, Christos ^{[2
]}

Meyer, Tim ^{[1
,2
]}

Caplin, Martyn ^{[2
]}

Beck, Stephan ^{[1
]}

Thirlwell, Christina ^{[1
,2
]}

机构：

[1] UCL, London, England

[2] Royal Free Hosp, London, England

[3] Broad Inst, Boston, MA USA

[4] UHN Princess Margaret Canc Ctr, Toronto, ON, Canada

[5] Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1530/ERC-16-0419

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：L21 / L25

页数：5

共 10 条

[1] Somatic Mutations and Genetic Heterogeneity at the CDKN1B Locus in Small Intestinal Neuroendocrine Tumors [J].

Crona, Joakim ;

Gustavsson, Tobias ;

Norlen, Olov ;

Edfeldt, Katarina ;

Akerstrom, Tobias ;

Westin, Gunnar ;

Hellman, Per ;

Bjorklund, Peyman ;

Stalberg, Peter .

ANNALS OF SURGICAL ONCOLOGY, 2015, 22 :S1428-S1435

[2]

Fazio N, 2016, ANTICANCER RES, V36, P713

[3] Somatic mutation of CDKN1B in small intestine neuroendocrine tumors [J].

Francis, Joshua M. ;

Kiezun, Adam ;

Ramos, Alex H. ;

Serra, Stefano ;

Pedamallu, Chandra Sekhar ;

Qian, Zhi Rong ;

Banck, Michaela S. ;

Kanwar, Rahul ;

Kulkarni, Amit A. ;

Karpathakis, Anna ;

Manzo, Veronica ;

Contractor, Tanupriya ;

Philips, Juliet ;

Nickerson, Elizabeth ;

Nam Pho ;

Hooshmand, Susanne M. ;

Brais, Lauren K. ;

Lawrence, Michael S. ;

Pugh, Trevor ;

McKenna, Aaron ;

Sivachenko, Andrey ;

Cibulskis, Kristian ;

Carter, Scott L. ;

Ojesina, Akinyemi I. ;

Freeman, Samuel ;

Jones, Robert T. ;

Voet, Douglas ;

Saksena, Gordon ;

Auclair, Daniel ;

Onofrio, Robert ;

Shefler, Erica ;

Sougnez, Carrie ;

Grimsby, Jonna ;

Green, Lisa ;

Lennon, Niall ;

Meyer, Tim ;

Caplin, Martyn ;

Chung, Daniel C. ;

Beutler, Andreas S. ;

Ogino, Shuji ;

Thirlwell, Christina ;

Shivdasani, Ramesh ;

Asa, Sylvia L. ;

Harris, Chris R. ;

Getz, Gad ;

Kulke, Matthew ;

Meyerson, Matthew .

NATURE GENETICS, 2013, 45 (12) :1483-U110

[4] Copy number alterations in small intestinal neuroendocrine tumors determined by array comparative genomic hybridization [J].

Hashemi, Jamileh ;

Fotouhi, Omid ;

Sulaiman, Luqman ;

Kjellman, Magnus ;

Hoog, Anders ;

Zedenius, Jan ;

Larsson, Catharina .

BMC CANCER, 2013, 13

[5]

Karpathakis A, 2016, CLIN CANCER RES, V22, P1483

[6] Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas [J].

Leja, Justyna ;

Essaghir, Ahmed ;

Essand, Magnus ;

Wester, Kenneth ;

Oberg, Kjell ;

Totterman, Thomas H. ;

Lloyd, Ricardo ;

Vasmatzis, George ;

Demoulin, Jean-Baptiste ;

Giandomenico, Valeria .

MODERN PATHOLOGY, 2009, 22 (02) :261-272

[7] Gastric inhibitory polypeptide receptor (GIPR) is a promising target for imaging and therapy in neuroendocrine tumors [J].

Sherman, Scott K. ;

Carr, Jennifer C. ;

Wang, Donghong ;

O'Dorisio, Sue ;

O'Dorisio, Thomas M. ;

Howe, James R. .

SURGERY, 2013, 154 (06) :1206-1213

[8] Global DNA methylation patterns through an array-based approach in small intestinal neuroendocrine tumors [J].

Verdugo, Alberto Delgado ;

Crona, Joakim ;

Starker, Lee ;

Stalberg, Peter ;

Akerstrom, Goran ;

Westin, Gunnar ;

Hellman, Per ;

Bjorklund, Peyman .

[9] One hundred years after "Carcinoid": Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States [J].

Yao, James C. ;

Hassan, Manal ;

Phan, Alexandria ;

Dagohoy, Cecile ;

Leary, Colleen ;

Mares, Jeannette E. ;

Abdalla, Eddie K. ;

Fleming, Jason B. ;

Vauthey, Jean-Nicolas ;

Rashid, Asif ;

Evans, Douglas B. .

JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (18) :3063-3072

[10] Everolimus for the treatment of advanced, non-functional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): a randomised, placebo-controlled, phase 3 study [J].

Yao, James C. ;

Fazio, Nicola ;

Singh, Simron ;

Buzzoni, Roberto ;

Carnaghi, Carlo ;

Wolin, Edward ;

Tomasek, Jiri ;

Raderer, Markus ;

Lahner, Harald ;

Voi, Maurizio ;

Pacaud, Lida Buboteishvili ;

Rouyrre, Nicolas ;

Sachs, Carolin ;

Valle, Juan W. ;

Delle Fave, Gianfranco ;

Van Cutsem, Eric ;

Tesselaar, Margot ;

Shimada, Yasuhiro ;

Oh, Do-Youn ;

Strosberg, Jonathan ;

Kulke, Matthew H. ;

Pavel, Marianne E. .

LANCET, 2016, 387 (10022) :968-977

← 1 →