The function of vascular endothelial growth factor

被引：86

作者：

Nieves, Bonnie J. ^{[1
]}

D'Amore, Patricia A. ^{[2
,3
,4
]}

Bryan, Brad A. ^{[1
]}

机构：

[1] Worcester State Coll, Dept Biol, Ghosh Sci & Technol Ctr, Worcester, MA USA

[2] Harvard Univ, Sch Med, Schepens Eye Res Inst, Boston, MA USA

[3] Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA USA

[4] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

BIOFACTORS | 2009年 / 35卷 / 04期

关键词：

VEGF; vascular endothelial growth factor; angiogenesis; endothelial cell; FACTOR VEGF; EXTRACELLULAR DOMAIN; PERMEABILITY FACTOR; TUMOR ANGIOGENESIS; FACTOR EXPRESSION; VISUAL FUNCTION; KINASE DOMAIN; TGF-BETA; RECEPTOR; CELLS;

D O I：

10.1002/biof.46

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular endothelial growth factor (VEGF) is considered the master regulator of angiogenesis during growth and development, as well as in disease states such as cancer, diabetes, and macular degeneration. This review details our current understanding of VEGF signaling and discusses the benefits and unexpected side effects of promising anti-angiogenic therapeutics that are currently being used to inhibit neovacularization in tumors.

引用

页码：332 / 337

页数：6

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