A new ESIPT-based fluorescent probe for highly selective and sensitive detection of hydrogen sulfide and its application in live-cell imaging

被引:24
作者
Chen, Bo [1 ]
Huang, Jing [1 ]
Geng, Huiqing [1 ]
Xuan, Lingli [1 ]
Xu, Tengfei [1 ]
Li, Xin [2 ]
Han, Yifeng [1 ]
机构
[1] Zhejiang Sci Tech Univ, Key Lab Adv Text Mat & Mfg Technol, Dept Chem, Hangzhou 310018, Zhejiang, Peoples R China
[2] Zhejiang Univ, Coll Pharmaceut Sci, ZJU ENS Joint Lab Med Chem, Hangzhou 310058, Zhejiang, Peoples R China
关键词
LARGE STOKES SHIFT; TURN-ON PROBE; LIVING CELLS; MOUSE HIPPOCAMPUS; METAL-IONS; H2S; RED; GASOTRANSMITTER; RECOGNITION; SULFUR;
D O I
10.1039/c6nj03355e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A new excited-state intramolecular proton transfer (ESIPT) based fluorescent probe for the detection of hydrogen sulfide has been reasonably designed and developed. The probe operates by H2S-mediated reduction of hydroxylamine to amine and exhibits high selectivity and sensitivity under mild conditions. Furthermore, the probe was successfully used for fluorescence imaging of H2S in living cells.
引用
收藏
页码:1119 / 1123
页数:5
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