Clinical Proton MR Spectroscopy in Central Nervous System Disorders

被引：481

作者：

OZ, Gulin ^{[1
]}

Alger, Jeffry R. ^{[2
]}

Barker, Peter B. ^{[3
]}

Bartha, Robert ^{[4
]}

Bizzi, Alberto ^{[5
]}

Boesch, Chris ^{[6
,7
]}

Bolan, Patrick J. ^{[1
]}

Brindle, Kevin M. ^{[8
]}

Cudalbu, Cristina ^{[9
]}

Dincer, Alp ^{[10
]}

Dydak, Ulrike ^{[11
]}

Emir, Uzay E. ^{[12
]}

Frahm, Jens ^{[13
]}

Gonzalez, Ramon Gilberto ^{[14
]}

Gruber, Stephan ^{[15
]}

Gruetter, Rolf ^{[9
]}

Gupta, Rakesh K. ^{[16
]}

Heerschap, Arend ^{[17
]}

Henning, Anke ^{[18
,19
]}

Hetherington, Hoby P. ^{[20
]}

Howe, Franklyn A. ^{[21
]}

Hueppi, Petra S. ^{[22
]}

Hurd, Ralph E. ^{[23
]}

Kantarci, Kejal ^{[24
]}

Klomp, Dennis W. J. ^{[25
]}

Kreis, Roland ^{[6
,7
]}

Kruiskamp, Marijn J. ^{[26
]}

Leach, Martin O. ^{[27
,28
]}

Lin, Alexander P. ^{[29
]}

Luijten, Peter R. ^{[25
]}

Marjanska, Malgorzata ^{[1
]}

Maudsley, Andrew A. ^{[30
]}

Meyerhoff, Dieter J. ^{[31
,32
]}

Mountford, Carolyn E. ^{[29
,33
]}

Nelson, Sarah J. ^{[34
]}

Pamir, M. Necmettin ^{[10
]}

Pan, Jullie W. ^{[35
]}

Peet, Andrew C. ^{[36
]}

Poptani, Harish ^{[37
]}

Posse, Stefan ^{[38
]}

Pouwels, Petra J. W. ^{[39
]}

Ratai, Eva-Maria ^{[14
]}

Ross, Brian D. ^{[40
]}

Scheenen, Tom W. J. ^{[17
]}

Schuster, Christian ^{[41
]}

Smith, Ian C. P. ^{[42
]}

Soher, Brian J. ^{[43
]}

Tkac, Ivan ^{[1
]}

Vigneron, Daniel B. ^{[34
]}

Kauppinen, Risto A. ^{[44
,45
]}

机构：

[1] Univ Minnesota, Ctr Magnet Resonance Res, 2021 6th St SE, Minneapolis, MN 55455 USA

[2] Univ Calif Los Angeles, Dept Radiol, Los Angeles, CA 90024 USA

[3] Johns Hopkins Univ, Dept Radiol, Sch Med, Baltimore, MD 21218 USA

[4] Univ Western Ontario, Robarts Res Inst, London, ON N6A 3K7, Canada

[5] Inst Clin Humanitas IRCCS, Neuroradiol Unit, Milan, Italy

[6] Univ Bern, Dept Radiol, CH-3012 Bern, Switzerland

[7] Univ Bern, Dept Clin Res, CH-3012 Bern, Switzerland

[8] Univ Cambridge, Dept Biochem, Cambridge CB2 1TN, England

[9] Ecole Polytech Fed Lausanne, CIBM, LIFMET, Lausanne, Switzerland

[10] Acibadem Univ, Sch Med, Istanbul, Turkey

[11] Purdue Univ, Sch Hlth Sci, W Lafayette, IN 47907 USA

[12] John Radcliffe Hosp, Oxford Ctr Funct MRI Brain FMRIB, Oxford, England

[13] Max Planck Inst Biophys Chem, Biomed NMR Forschungs GmbH, Gottingen, Germany

[14] Harvard Univ, Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA

[15] Med Univ Vienna, Dept Radiol, Vienna, Austria

[16] Sanjay Gandhi Post Grad Inst Med Sci, Dept Radiol, Lucknow, Uttar Pradesh, India

[17] Radboud Univ Nijmegen, Dept Radiol, NL-6525 ED Nijmegen, Netherlands

[18] Max Planck Inst Biol Cybernet, Tubingen, Germany

[19] Swiss Fed Inst Technol, Inst Biomed Engn, Zurich, Switzerland

[20] Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15260 USA

[21] St George Univ London, Clin Sci, London WC1E 7HU, England

[22] Univ Geneva, Dept Pediat, CH-1211 Geneva 4, Switzerland

[23] Gen Elect Healthcare, Menlo Pk, CA USA

[24] Mayo Clin, Dept Radiol, Rochester, MI USA

[25] Univ Med Ctr Utrecht, Utrecht, Netherlands

[26] Philips Healthcare, Best, Netherlands

[27] Univ London, Inst Canc Res, EPSRC Canc Imaging Ctr, Sutton, Surrey, England

[28] Univ London, Inst Canc Res, CR UK, Sutton, Surrey, England

[29] Harvard Univ Med Sch, Brigham & Womens Hosp, Ctr Clin Spectroscopy, Ctr MR Hlth, Boston, MA USA

[30] Miami Univ, Dept Radiol, Miami, FL USA

[31] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA

[32] Univ Calif San Francisco, DVA Med Ctr, San Francisco, CA 94143 USA

[33] Univ Newcastle, Ctr MR Hlth, Newcastle, NSW, Australia

[34] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA

[35] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

[36] Univ Birmingham, Dept Canc Sci, Birmingham B15 2TT, W Midlands, England

[37] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

[38] Univ New Mexico, Dept Neurol, Albuquerque, NM 87131 USA

[39] Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands

[40] Huntington Med Res Ctr, Pasadena, CA USA

[41] Siemens Healthcare, Erlangen, Germany

[42] Innovat Biodiagnost, Winnipeg, MB, Canada

[43] Duke Univ, Med Ctr, Durham, NC 27706 USA

[44] Univ Bristol, Clin Res & Imaging Ctr, Bristol BS8 1TH, Avon, England

[45] Univ Bristol, Sch Expt Psychol, Bristol BS8 1TH, Avon, England

来源：

RADIOLOGY | 2014年 / 270卷 / 03期

基金：

英国工程与自然科学研究理事会; 瑞士国家科学基金会; 英国医学研究理事会;

关键词：

MAGNETIC-RESONANCE-SPECTROSCOPY; LOCALIZED H-1-NMR SPECTROSCOPY; MILD COGNITIVE IMPAIRMENT; BRAIN N-ACETYLASPARTATE; WHITE-MATTER DISORDERS; T-2; RELAXATION-TIMES; IN-VIVO; MULTIPLE-SCLEROSIS; SHORT-ECHO; H-1; MRS;

D O I：

10.1148/radiol.13130531

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A large body of published work shows that proton (hydrogen 1 [H-1]) magnetic resonance (MR) spectroscopy has evolved from a research tool into a clinical neuroimaging modality. Herein, the authors present a summary of brain disorders in which MR spectroscopy has an impact on patient management, together with a critical consideration of common data acquisition and processing procedures. The article documents the impact of 1H MR spectroscopy in the clinical evaluation of disorders of the central nervous system. The clinical usefulness of 1H MR spectroscopy has been established for brain neoplasms, neonatal and pediatric disorders (hypoxia-ischemia, inherited metabolic diseases, and traumatic brain injury), demyelinating disorders, and infectious brain lesions. The growing list of disorders for which 1H MR spectroscopy may contribute to patient management extends to neurodegenerative diseases, epilepsy, and stroke. To facilitate expanded clinical acceptance and standardization of MR spectroscopy methodology, guidelines are provided for data acquisition and analysis, quality assessment, and interpretation. Finally, the authors offer recommendations to expedite the use of robust MR spectroscopy methodology in the clinical setting, including incorporation of technical advances on clinical units. (c) RSNA, 2014

引用

页码：658 / 679

页数：22

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