What is the role of autoimmunity in type 1 diabetes? A clinical perspective

被引：37

作者：

Donath, Marc Y. ^{[1
,2
,3
]}

Hess, Christoph ^{[2
,3
,4
]}

Palmer, Ed ^{[2
,3
,5
]}

机构：

[1] Univ Basel Hosp, CH-4031 Basel, Switzerland

[2] Univ Basel, CH-4031 Basel, Switzerland

[3] Univ Basel Hosp, Dept Biomed, CH-4031 Basel, Switzerland

[4] Univ Basel Hosp, Med Outpatient Clin, CH-4031 Basel, Switzerland

[5] Univ Basel Hosp, Lab Transplantat Immunol, CH-4031 Basel, Switzerland

来源：

DIABETOLOGIA | 2014年 / 57卷 / 04期

关键词：

Autoimmunity; Beta cells; Clinic; Type; 1; diabetes; PLACEBO-CONTROLLED TRIAL; RECENT-ONSET; DOUBLE-BLIND; MONOCLONAL-ANTIBODY; C-PEPTIDE; DISEASE; MULTICENTER; DIAGNOSIS; THERAPY; TERM;

D O I：

10.1007/s00125-013-3153-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Despite tremendous research efforts, type 1 diabetes is one of the few remaining autoimmune diseases without any approved immunological treatment. This observation compels us to reconsider the role of autoimmunity in the pathogenesis of this disease. In this commentary, we will review solely human data in an attempt to appreciate, in an unbiased manner, the importance and relevance of the immunological alterations in patients with type 1 diabetes. The aim of this paper is to generate reflection on this topic, rather than a controversy.

引用

页码：653 / 655

页数：3

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