Lassa virus

被引：150

作者：

Günther, S

Lenz, O

机构：

[1] Bernhard Nocht Inst Trop Med, Dept Virol, D-20359 Hamburg, Germany

[2] European Mol Biol Lab, Grenoble Outstn, F-38042 Grenoble, France

来源：

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES | 2004年 / 41卷 / 04期

关键词：

arenavirus; lymphocytic choriomeningitis virus; Lassa fever; phylogeny; molecular diagnostics;

D O I：

10.1080/10408360490497456

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Lassa virus is a RNA virus belonging to the family of Arenaviridae. It was discovered as the causative agent of a hemorrhagic fever-Lassa fever-about 30 years ago. Lassa fever is endemic in West Africa and is estimated to affect some 100,000 people annually. Great progress in the understanding of the life cycle of arenaviruses, including Lassa virus, has been made in recent years. New insights have been gained in the pathogenesis and molecular epidemiology of Lassa fever, and state-of the-art technologies for diagnosing this Life-threatening disease have been developed. The intention of this review is to summarize in particular the recent literature on Lassa virus and Lassa fever. Several aspects ranging from basic research up to clinical practice and laboratory diagnosis are discussed and linked together.

引用

页码：339 / 390

页数：52

共 324 条

[1] INVITRO SELECTION OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS ESCAPE MUTANTS BY CYTOTOXIC LYMPHOCYTES-T [J].