Inhibition of breast cancer metastasis by paclitaxel-loaded pH responsive poly(β-amino ester) copolymer micelles

被引：21

作者：

Chen, Yanjun ^{[1
]}

Yue, Qiaoxin ^{[1
]}

De, Gejing ^{[1
]}

Wang, Jie ^{[1
]}

Li, Zhenzhen ^{[1
]}

Xiao, Shuiming ^{[1
]}

Yu, Huatao ^{[1
]}

Ma, Hai ^{[1
]}

Sui, Feng ^{[1
]}

Zhao, Qinghe ^{[1
]}

机构：

[1] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

来源：

NANOMEDICINE | 2017年 / 12卷 / 02期

关键词：

anticancer; invasion; metastasis; migration; paclitaxel; poly(beta-amino ester); ALBUMIN-BOUND PACLITAXEL; POLYMERIC MICELLES; CREMOPHOR-FREE; IN-VITRO; NANOPARTICLES; CELLS; ANTICANCER; RESISTANCE; DOXORUBICIN; DELIVERY;

D O I：

10.2217/nnm-2016-0335

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: Tumor metastasis is one of the leading causes of insufficient chemotherapy during cancer treatment. In this study, a poly(beta-amino ester) derivate was developed to fabricate paclitaxel (PTX) entrapped pH-responsive copolymer micelles for inhibition of breast cancer metastasis. Materials & methods: PTX-loaded micelles were fabricated by thin film hydration method. The inhibition efficacy of the as-prepared micelles was evaluated on MDA-MB-231 cells and tumor bearing mice. Results: PTX-loaded micelles were successfully prepared. Such micelles could promote drug uptake and MDA-MB-231 cell deaths, and suppress tumor metastasis. Conclusion: The pH-responsive PTX-loaded micelles are promising candidates in developing stimuli triggered drug delivery systems in acidic tumor microenvironments with improved inhibitory effects on tumor metastasis.

引用

页码：147 / 164

页数：18

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