Inhibition of breast cancer metastasis by paclitaxel-loaded pH responsive poly(β-amino ester) copolymer micelles

被引：21

作者：

Chen, Yanjun ^{[1
]}

Yue, Qiaoxin ^{[1
]}

De, Gejing ^{[1
]}

Wang, Jie ^{[1
]}

Li, Zhenzhen ^{[1
]}

Xiao, Shuiming ^{[1
]}

Yu, Huatao ^{[1
]}

Ma, Hai ^{[1
]}

Sui, Feng ^{[1
]}

Zhao, Qinghe ^{[1
]}

机构：

[1] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

来源：

NANOMEDICINE | 2017年 / 12卷 / 02期

关键词：

anticancer; invasion; metastasis; migration; paclitaxel; poly(beta-amino ester); ALBUMIN-BOUND PACLITAXEL; POLYMERIC MICELLES; CREMOPHOR-FREE; IN-VITRO; NANOPARTICLES; CELLS; ANTICANCER; RESISTANCE; DOXORUBICIN; DELIVERY;

D O I：

10.2217/nnm-2016-0335

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: Tumor metastasis is one of the leading causes of insufficient chemotherapy during cancer treatment. In this study, a poly(beta-amino ester) derivate was developed to fabricate paclitaxel (PTX) entrapped pH-responsive copolymer micelles for inhibition of breast cancer metastasis. Materials & methods: PTX-loaded micelles were fabricated by thin film hydration method. The inhibition efficacy of the as-prepared micelles was evaluated on MDA-MB-231 cells and tumor bearing mice. Results: PTX-loaded micelles were successfully prepared. Such micelles could promote drug uptake and MDA-MB-231 cell deaths, and suppress tumor metastasis. Conclusion: The pH-responsive PTX-loaded micelles are promising candidates in developing stimuli triggered drug delivery systems in acidic tumor microenvironments with improved inhibitory effects on tumor metastasis.

引用

页码：147 / 164

页数：18

共 60 条

[11] The Serine Protease Inhibitor Protease Nexin-1 Controls Mammary Cancer Metastasis through LRP-1-Mediated MMP-9 Expression [J].

Fayard, Berengere ;

Bianchi, Fabrizio ;

Dey, Julien ;

Moreno, Eliza ;

Djaffer, Sabrina ;

Hynes, Nancy E. ;

Monard, Denis .

CANCER RESEARCH, 2009, 69 (14) :5690-5698

[12]

FIDLER IJ, 1990, CANCER RES, V50, P6130

[13] Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity [J].

Fonseca, C ;

Simoes, S ;

Gaspar, R .

JOURNAL OF CONTROLLED RELEASE, 2002, 83 (02) :273-286

[14] Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation [J].

Gelderblom, H ;

Verweij, J ;

Nooter, K ;

Sparreboom, A .

EUROPEAN JOURNAL OF CANCER, 2001, 37 (13) :1590-1598

[15] Efficient inhibition of colorectal peritoneal carcinomatosis by drug loaded micelles in thermosensitive hydrogel composites [J].

Gong, ChangYang ;

Wang, Cheng ;

Wang, YuJun ;

Wu, QinJie ;

Zhang, DouDou ;

Luo, Feng ;

Qian, ZhiYong .

NANOSCALE, 2012, 4 (10) :3095-3104

[16] Lysosomal Sequestration of Sunitinib: A Novel Mechanism of Drug Resistance [J].

Gotink, Kristy J. ;

Broxterman, Henk J. ;

Labots, Mariette ;

de Haas, Richard R. ;

Dekker, Henk ;

Honeywell, Richard J. ;

Rudek, Michelle A. ;

Beerepoot, Laurens V. ;

Musters, Rene J. ;

Jansen, Gerrit ;

Griffioen, Arjan W. ;

Assaraf, Yehuda G. ;

Pili, Roberto ;

Peters, Godefridus J. ;

Verheul, Henk M. W. .

CLINICAL CANCER RESEARCH, 2011, 17 (23) :7337-7346

[17] Albumin-bound paclitaxel: a next-generation taxane [J].

Gradishar, William J. .

EXPERT OPINION ON PHARMACOTHERAPY, 2006, 7 (08) :1041-1053

[18] Electrostatic ligand coatings of nanoparticles enable ligand-specific gene delivery to human primary cells [J].

Green, Jordan J. ;

Chiu, Eugene ;

Leshchiner, Elizaveta S. ;

Shi, Julie ;

Langer, Robert ;

Anderson, Daniel G. .

NANO LETTERS, 2007, 7 (04) :874-879

[19] Poly(lactic acid)-poly(ethylene oxide) (PLA-PEG) nanoparticles: NMR studies of the central solidlike PLA core and the liquid PEG corona [J].

Heald, CR ;

Stolnik, S ;

Kujawinski, KS ;

De Matteis, C ;

Garnett, MC ;

Illum, L ;

Davis, SS ;

Purkiss, SC ;

Barlow, RJ ;

Gellert, PR .

LANGMUIR, 2002, 18 (09) :3669-3675

[20] pH-Sensitivity control of PEG-Poly(β-amino ester) block copolymer micelle [J].

Hwang, Su Jong ;

Kim, Min Sang ;

Han, Jong Kwon ;

Lee, Doe Sung ;

Kim, Bong Sup ;

Choi, Eun Kyung ;

Park, Heon Joe ;

Kim, An Seek .

MACROMOLECULAR RESEARCH, 2007, 15 (05) :437-442

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