Coinfection with Zika Virus (ZIKV) and Dengue Virus Results in Preferential ZIKV Transmission by Vector Bite to Vertebrate Host

被引：43

作者：

Chaves, Barbara Aparecida ^{[1
,2
]}

Orfano, Alessandra Silva ^{[3
]}

Nogueira, Paula Monalisa ^{[3
]}

Rodrigues, Nilton Barnabe ^{[3
]}

Campolina, Thais Bonifacio ^{[3
]}

Nacif-Pimenta, Rafael ^{[3
]}

Araujo Machado Pires, Ana Clara ^{[3
]}

Vieira Junior, Ademir Bentes ^{[1
]}

Paz, Andreia da Costa ^{[1
]}

da Costa Vaz, Evelyn Beatriz ^{[1
,2
]}

Vale Barbosa Guerra, Maria das Gracas ^{[1
]}

Silva, Breno Melo ^{[4
]}

de Melo, Fabricio Freire ^{[5
]}

Norris, Douglas Eric ^{[6
]}

Guimaraes de lacerda, Marcus Vinicius ^{[1
,2
,7
]}

Paolucci Pimenta, Paulo Filemon ^{[1
,2
,3
]}

Costa Secundino, Nagila Francinete ^{[2
,3
]}

机构：

[1] Fundacao Med Trop Dr Heitor Vieira Dourado, Inst Pequisa Clin Carlos Borborema, Manaus, Amazonas, Brazil

[2] Univ Estado Amazonas, Programa Posgrad Med Trop, Manaus, Amazonas, Brazil

[3] Fundacao Oswaldo Cruz, Inst Rene Rachou, Av Augusto de Lima 1715, BR-30190002 Belo Horizonte, MG, Brazil

[4] Univ Fed Ouro Preto, Dept Ciencias Biol, Ouro Preto, MG, Brazil

[5] Univ Fed Bahia, Inst Multidisciplinar Saude, Vitoria Da Conquista, Brazil

[6] Johns Hopkins Bloomberg Sch Publ Hlth, W Harry Feinstone Dept Mol Microbiol & Immunol, Baltimore, MD USA

[7] Fundacao Oswaldo Cruz, Inst Leonidas & Maria Deane, Manaus, Amazonas, Brazil

来源：

JOURNAL OF INFECTIOUS DISEASES | 2018年 / 218卷 / 04期

关键词：

Coinfection; Aedes aegypti; Zika virus; dengue virus; preferential transmission; vector bite; CHIKUNGUNYA VIRUS; AEDES-AEGYPTI; CLINICAL PRESENTATION; INFECTION; EPIDEMIC; BRAZIL;

D O I：

10.1093/infdis/jiy196

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Several tropical cities are permissive to Aedes aegypti and dengue virus (DENV) endemicity and have allowed for invasion and circulation of Zika virus (ZIKV) in the same areas. People living in arbovirus-endemic regions have been simultaneously infected with >= 2 arboviruses. Methods. A. aegypti mosquitoes from Manaus, the capital city of Amazonas State in Brazil, were coinfected with circulating strains of DENV and ZIKV. The coinfected vectors were allowed to bite BALB/c mice. Results. A. aegypti from Manaus is highly permissive to monoinfection and coinfection with DENV and ZIKV and is capable of cotransmitting both pathogens by bite. Coinfection strongly influences vector competence, favoring transmission of ZIKV to the vertebrate host. Conclusions. This finding suggests that A. aegypti is an efficient vector of ZIKV and that ZIKV would be preferentially transmitted by coinfected A. aegypti. Coinfection in the vector population should be considered a new critical epidemiological factor and may represent a major public health challenge.

引用

页码：563 / 571

页数：9

共 36 条

[1] Zika and chikungunya infections in Brazil: reviewing the epidemic and treatment options [J].

Alves Esposito, Danillo Lucas ;

Lopes da Fonseca, Benedito Antonio .

REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 2016, 49 (05) :535-536

[2]

[Anonymous], NUMB REP CAS DENG SE

[3]

[Anonymous], 2017, ZIK CAS CONG SYNDR A

[4]

[Anonymous], 2016, WHO DIRECTOR GEN SUM

[5]

[Anonymous], MON CAS DENG FEBR CH

[6]

[Anonymous], EURO SURVEILL

[7] Variation in vector competence for dengue 2 virus among 24 collections of Aedes aegypti from Mexico and the United States [J].

Bennett, KE ;

Olson, KE ;

Muñoz, MD ;

Fernandez-Salas, I ;

Farfan-Ale, JA ;

Higgs, S ;

Black, WC ;

Beaty, BJ .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2002, 67 (01) :85-92

[8] The global distribution and burden of dengue [J].

Bhatt, Samir ;

Gething, Peter W. ;

Brady, Oliver J. ;

Messina, Jane P. ;

Farlow, Andrew W. ;

Moyes, Catherine L. ;

Drake, John M. ;

Brownstein, John S. ;

Hoen, Anne G. ;

Sankoh, Osman ;

Myers, Monica F. ;

George, Dylan B. ;

Jaenisch, Thomas ;

Wint, G. R. William ;

Simmons, Cameron P. ;

Scott, Thomas W. ;

Farrar, Jeremy J. ;

Hay, Simon I. .

NATURE, 2013, 496 (7446) :504-507

[9] Isolation of Infective Zika Virus from Urine and Saliva of Patients in Brazil [J].

Bonaldo, Myrna C. ;

Ribeiro, Ieda P. ;

Lima, Noemia S. ;

dos Santos, Alexandre A. C. ;

Menezes, Lidiane S. R. ;

da Cruz, Stephanie O. D. ;

de Mello, Iasmim S. ;

Furtado, Nathalia D. ;

de Moura, Elaine E. ;

Damasceno, Luana ;

da Silva, Kely A. B. ;

de Castro, Marcia G. ;

Gerber, Alexandra L. ;

de Almeida, Luiz G. P. ;

Lourenco-de-Oliveira, Ricardo ;

Vasconcelos, Ana Tereza R. ;

Brasil, Patricia .

PLOS NEGLECTED TROPICAL DISEASES, 2016, 10 (06)

[10]

BOORMAN J. P. T., 1956, TRANS ROY SOC TROP MED AND HYG, V50, P238, DOI 10.1016/0035-9203(56)90029-3

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