Curcumin ameliorates DSS-induced colitis in mice by regulating the Treg/Th17 signaling pathway

被引：55

作者：

Wei, Cheng ^{[1
]}

Wang, Jian-Yao ^{[2
]}

Xiong, Feng ^{[1
]}

Wu, Ben-Hua ^{[1
]}

Luo, Ming-Han ^{[1
]}

Yu, Zhi-Chao ^{[1
]}

Liu, Ting-Ting ^{[1
]}

Li, De-Feng ^{[1
]}

Tang, Qi ^{[1
]}

Li, Ying-Xue ^{[1
]}

Zhang, Ding-Guo ^{[1
]}

Xu, Zheng-Lei ^{[1
]}

Jin, Hong-Tao ^{[1
]}

Wang, Li-Sheng ^{[1
]}

Yao, Jun ^{[1
]}

机构：

[1] Jinan Univ Second Clin Med Sci, Shenzhen Municipal Peoples Hosp, Dept Gastroenterol, 1017 East Gate Rd, Shenzhen 518020, Guangdong, Peoples R China

[2] Shenzhen Childrens Hosp, Dept Gen Surg, Shenzhen 518026, Guangdong, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2021年 / 23卷 / 01期

关键词：

curcumin; T helper 17 cells; T regulatory cells; inflammatory bowel disease; INFLAMMATORY-BOWEL-DISEASE; ULCERATIVE-COLITIS; MUCOSAL IMMUNITY; TH17; CELLS; T-CELLS; CYTOKINES; PREVENTS; AXIS;

D O I：

10.3892/mmr.2020.11672

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Curcumin has a therapeutic effect on ulcerative colitis, but the underlying mechanism has yet to be elucidated. The aim of the present study was to clarify the possible mechanisms. Dextran sulfate sodium-induced colitis mice were treated with curcumin via gavage for 7 days. The effects of curcumin on disease activity index (DAI) and pathological changes of colonic tissue in mice were determined. Interleukin (IL)-6, IL-10, IL-17 and IL-23 expression levels were measured by ELISA. Flow cytometry was used to detect the ratio of mouse spleen regulatory T cells (Treg)/Th17 cells, and western blotting was used to measure the nuclear protein hypoxia inducible factor (HIF)-1 alpha level. The results demonstrated that curcumin can significantly reduce DAI and spleen index scores and improve mucosal inflammation. Curcumin could also regulate the re-equilibration of Treg/Th17. IL-10 level in the colon was significantly increased, while inflammatory cytokines IL-6, IL-17 and IL-23 were significantly reduced following curcumin treatment. No significant difference in HIF-1 alpha was observed between the colitis and the curcumin group. It was concluded that oral administration of curcumin can effectively treat experimental colitis by regulating the re-equilibration of Treg/Th17 and that the regulatory mechanism may be closely related to the IL-23/Th17 pathway. The results of the present study provided molecular insight into the mechanism by which curcumin treats ulcerative colitis.

引用

页码：1 / 7

页数：7

共 37 条

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