Docosahexaenoic Acid Ethyl Ester Enhances 6-Hydroxydopamine-Induced Neuronal Damage by Induction of Lipid Peroxidation in Mouse Striatum

被引:23
作者
Kabuto, Hideaki [1 ]
Amakawa, Masao [1 ,2 ]
Mankura, Mitsumasa
Yamanushi, Tomoko T. [1 ]
Mori, Akitane [2 ]
机构
[1] Kagawa Prefectural Coll Hlth Sci, Dept Hlth Sci, Takamatsu, Kagawa 7610123, Japan
[2] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Antiaging Food Sci, Okayama 7008558, Japan
关键词
Parkinson disease; DHA ethyl ester; Dopamine; Lipid peroxidation; POLYUNSATURATED FATTY-ACIDS; PARKINSONS-DISEASE; OXIDATIVE STRESS; BRAIN; RAT; APOPTOSIS; NEURODEGENERATION; NEUROTOXICITY; GLUTATHIONE; MECHANISM;
D O I
10.1007/s11064-008-9909-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Superoxide and hydroxyl radicals are implicated in the pathogenesis of Parkinson disease, and induction of lipid peroxidation is an important factor in progression of this disease. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. However, DHA has neuroprotective effects. In this study, we examined the effects of intraperitoneal injection (ipi) of DHA ethyl ester (DHA-Et) on 6-hydroxydopamine (6-OHDA)-induced dopamine (DA) reduction in the mouse striatum. DHA-Et ipi for 7 days before and 7 days after a single intracerebroventricular injection of 6-OHDA enhanced 6-OHDA-induced reduction of striatal DA level. On the other hand, ipi of DHA-Et for 7 days increased its concentration in the striatum. Co-injection of DHA-Et and 6-OHDA increased the levels of thiobarbituric acid-reactive substances (a marker of lipid peroxidation) in the striatum. Our results suggest that DHA-Et enhances 6-OHDA-induced DA depression by increasing lipid peroxidation, and that excessive use of DHA-Et may increase the susceptibility of Parkinson disease in animal model.
引用
收藏
页码:1299 / 1303
页数:5
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