Adipose Tissue Immune Response: Novel Triggers and Consequences for Chronic Inflammatory Conditions

被引：151

作者：

Ghigliotti, Giorgio ^{[1
]}

Barisione, Chiara ^{[1
]}

Garibaldi, Silvano ^{[1
]}

Fabbi, Patrizia ^{[1
]}

Brunelli, Claudio ^{[1
]}

Spallarossa, Paolo ^{[1
]}

Altieri, Paola ^{[1
]}

Rosa, Gianmarco ^{[1
]}

Spinella, Giovanni ^{[2
]}

Palombo, Domenico ^{[2
]}

Arsenescu, Razvan ^{[3
]}

Arsenescu, Violeta ^{[4
]}

机构：

[1] Univ Genoa, Div Cardiol, IRCCS Univ Hosp San Martino, Res Ctr Cardiovasc Biol, Genoa, Italy

[2] Univ Genoa, Vasc & Endovasc Surg Unit, Genoa, Italy

[3] Ohio State Univ, IBD Ctr, Div Gastroenterol Hepatol & Nutr, Columbus, OH 43210 USA

[4] Ohio State Univ, Div Gastroenterol Hepatol & Nutr, Mucosal Immunol IBD Lab, Columbus, OH 43210 USA

来源：

INFLAMMATION | 2014年 / 37卷 / 04期

关键词：

adipose tissue; inflammation; macrophage; NK; NKT; eosinophil; neutrophil; adiponectin; angiotensin; aryl hydrocarbon receptor; abdominal aortic aneurysm; mast cell inflammatory bowel disease; cardiorenal syndrome; chronic inflammatory diseases; uric acid; RENIN-ANGIOTENSIN SYSTEM; CHRONIC KIDNEY-DISEASE; HIGH-MOLECULAR-WEIGHT; DIET-INDUCED OBESITY; PROMOTES MACROPHAGE POLARIZATION; ABDOMINAL AORTIC-ANEURYSM; INVARIANT NKT CELLS; REGULATORY T-CELLS; INSULIN-RESISTANCE; MAST-CELLS;

D O I：

10.1007/s10753-014-9914-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Adipose tissue inflammation mediates the association between excessive body fat accumulation and several chronic inflammatory diseases. A high prevalence of obesity-associated adipose tissue inflammation was observed not only in patients with cardiovascular conditions but also in patients with inflammatory bowel diseases, abdominal aortic aneurysm, or cardiorenal syndrome. In addition to excessive caloric intake, other triggers promote visceral adipose tissue inflammation followed by chronic, low-grade systemic inflammation. The infiltration and accumulation of immune cells in the inflamed and hypertrophied adipose tissue promote the production of inflammatory cytokines, contributing to target organ damages. This comorbidity seems to delimit subgroups of individuals with systemic adipose tissue inflammation and more severe chronic inflammatory diseases that are refractory to conventional treatment. This review highlights the association between adipose tissue immune response and the pathophysiology of visceral adiposity-related chronic inflammatory diseases, while suggesting several new therapeutic strategies.

引用

页码：1337 / 1353

页数：17

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