Loss of heterozygosity and microsatellite DNA instability on chromosomes 3 and 9 in esophageal cancer tissues

被引：0

作者：

Li, WD

Wang, L

Wang, XQ

Wu, M

Zhang, CL

Zhang, T

Mao, XZ

机构：

[1] CHINESE ACAD MED SCI, PEKING UNION MED COLL, DEPT CELL BIOL, STATE KEY LAB MOLEC ONCOL, BEIJING 100021, PEOPLES R CHINA

[2] CANC INST YANGQUAN, YANGQUAN 045000, PEOPLES R CHINA

来源：

PROGRESS IN NATURAL SCIENCE | 1996年 / 6卷 / 04期

关键词：

loss of heterozygosity; microsatellite DNA instability; esophageal cancer;

D O I：

暂无

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Loss of heterozygosity and microsatellite DNA instability in 36 pairs of sporadic esophageal and their corresponding normal tissue were detected by microsatellite DNA polymorphism-PCR-silver stain method by using 10 pairs of primers on chromosomes 3 and 9. High frequency of loss of heterozygosity was found on loci of 9p22-23, 3p23, 3p14.2, 3p21.3 and 3p21-22. It is suggested that then may be dues of turner suppressor genes. Simultaneously, high frequency of microsatellite DNA instability was also detected on some chromosome loci. Widespread microsatellite instability not only exists in familial cancer, but also in sporadic tumors.

引用

页码：458 / 464

页数：7

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