Protein-based fluorescent metal nanoclusters for small molecular drug screening

被引：61
作者：
Yu, Yong [1 ]
New, Siu Yee [1 ]
Xie, Jianping [2 ]
Su, Xiaodi [1 ]
Tan, Yen Nee [1 ]
机构：
[1] Inst Mat Res & Engn, Singapore 117602, Singapore
[2] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 119260, Singapore
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 89期
关键词：
GOLD NANOCLUSTERS; SILVER NANOCLUSTERS; HIGHLY LUMINESCENT; IN-VITRO; CLUSTERS; NANOPARTICLES; PEPTIDE; EMISSION;
D O I：
10.1039/c4cc06914e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile drug screening method based on synthesis of fluorescent gold nanoclusters inside albumin proteins loaded with small molecular drugs and comparing the relative fluorescence intensities of the resultant gold nanoclusters has been developed and successfully applied for the quantitative measurement of drug-protein binding constants.
引用
收藏
页码：13805 / 13808
页数：4
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